According to WeChat official account, the Beijing Fire WeChat, the investigation report of the "5 9" major fire accident in Tongzhou District was released. At about 13: 45 on May 9, 2021, a fire broke out in the warehouse of Beijing Longhao Meat Food Co., Ltd. (hereinafter referred to as Longhao Company) located in Zhangjiawan Town, Tongzhou District, Beijing, with an area of over 3,000 square meters, resulting in three deaths and direct property losses of 3,090,700 yuan. The fire rescue agency determined that the fire site of this fire accident was located at the ground in the south-central part of the cold storage on the east side of the west yard of Longhao Company; Combined with the field experiment and inspection and identification, it is determined that the fire is caused by the ignition of thermal insulation materials during construction.

Investigation report on "5 9" major fire accident in Tongzhou District

At about 13: 45 on May 9, 2021, a fire broke out in the warehouse of Beijing Longhao Meat Food Co., Ltd. (hereinafter referred to as Longhao Company) located in Zhangjiawan Town, Tongzhou District, Beijing, with an area of over 3,000 square meters, resulting in three deaths and direct property losses of 3,090,700 yuan.

After the fire broke out, the relevant city leaders made important instructions. According to the Emergency Response Law of People’s Republic of China (PRC) and the Fire Prevention Law of People’s Republic of China (PRC), and referring to the Regulations on the Reporting, Investigation and Handling of Production Safety Accidents and other relevant laws and regulations, the municipal government established a fire accident investigation team composed of the Municipal Emergency Bureau, the Municipal Fire Rescue Corps, the Municipal Public Security Bureau, the Municipal Human Resources and Social Security Bureau, the Municipal Federation of Trade Unions and the Tongzhou District Government, and invited the Municipal Commission for Discipline Inspection and the Municipal Supervision Committee to participate in the accident investigation and comprehensively carry out the accident investigation and handling work.

In accordance with the principles of "four no-misses" and "scientific rigor, compliance with laws and regulations, seeking truth from facts and paying attention to practical results", the accident investigation team conducted on-site inspection, consulting materials, video analysis and appraisal tests, and entrusted technical appraisal institutions to carry out sampling analysis and technical appraisal of relevant physical evidence extracted from the accident site, found out the course and cause of the accident, identified the nature and responsibility of the accident, and put forward suggestions on handling the relevant responsible personnel and units. The relevant situation is now reported as follows:

I. Basic information

(a) the basic situation of the building.

The incident building is located in West dingfuzhuang Village, Zhangjiawan Town, Tongzhou District, Beijing, the southwest corner of Tongzhou Aquaculture Farm (hereinafter referred to as Tongzhou Aquaculture Farm) and the warehouse of Longhao Company’s West Campus. Longhao Company covers an area of about 18 mu, and the total height of the warehouse building is about 5.9 meters, with a construction area of about 3,100 square meters. The south wall of the warehouse is about 98 meters long, the north wall is about 99 meters long, the east wall is about 39 meters wide, and the west wall is about 24 meters wide. The main building is steel structure, supported by I-shaped steel columns, the outer wall is rock wool sandwich color steel plate, and it is a single-story building with no ceiling and partition inside.

Figure 1 Schematic diagram of the building layout of the incident warehouse

Before the incident, the warehouse was being rebuilt. It is planned to divide the interior of the warehouse into three cold storages, the east, the middle and the west. The height of the cold storage is about 4.5 meters, and a mezzanine is formed between the top plate of the cold storage and the top of the building. Only one entrance to the mezzanine construction is left on the top plate on the north side of the west library for the elevator to transport personnel and construction tools, and other parts are not connected with the mezzanine. The cold storage under construction uses polyurethane thermal insulation board as the wall, partition and roof material, and there is a gap of about 10 cm between the roof of the cold storage and the I-beam column, and the extruded board is laid on the ground of the warehouse. When the fire broke out, two-thirds of the ground in the east warehouse of the cold storage had been paved with extruded boards from the south to the north, and the rest had not yet begun to be paved.

(2) Information about the accident-related units

1. Tongzhou Aquaculture Farm, the legal representative is Zhang Qiang (deputy director, responsible for specific business work), and the actual person in charge is Zhang Baohua (in charge of the overall work of the farm). The unified social credit code is 12110112400952617P, which belongs to the Agricultural and Rural Bureau of Tongzhou District, Beijing, and is a self-financing institution. Its domicile is in the south of Zhangjiawan Town Government, Tongzhou District, Beijing. Its purpose and business scope are to provide excellent seedlings and advanced technologies.

2. Longhao Company, whose legal representative is Li Hailong, unified social credit code is 91110112102394450X, registered address is West dingfuzhuang Village, Zhangjiawan Town, Tongzhou District, Beijing, and its business scope is slaughtering cattle, selling cattle, sheep, livestock and poultry, import and export of goods, building materials, etc., and it has the license for slaughtering and processing beef cattle.

3. Beijing Boyujie Trading Co., Ltd. (hereinafter referred to as Boyujie Company), the legal representative is Jiang Changzheng, the unified social credit code is 91110112327310107C, the registered address is No.9 -477 Yongle Street, Yongledian Town, Tongzhou District, Beijing, and its business scope covers sales of hardware and electric materials, building materials, labor subcontracting, engineering survey and design, etc.

4. Beijing Youliang Refrigeration Equipment Co., Ltd. (hereinafter referred to as Youliang Company), whose legal representative is Wanlicheng, unified social credit code is 91110228MA01KT6P9M, registered address is Room 402 -1791, Shicheng Town Government Office Building, Miyun District, Beijing, and its business scope covers sales of air-conditioning refrigeration equipment, installation and maintenance of air-conditioning refrigeration equipment, labor subcontracting, general construction contracting, etc.

(three) the approval and rental construction of the above-ground housing planning on the land where the incident occurred

1. The above-ground housing planning approval.

The land in question is located in West dingfuzhuang Village, Zhangjiawan Town, Tongzhou District. The owner is Tongzhou Aquaculture Farm. The land certificate number is Jing Tong Guo Yong (2010 Plot) No.004, and the parcel area is 238,236.85 square meters. It is used as industrial land, and the ownership is state-owned and the use right type is allocated.

On June 19th, 2007, Beijing Tongzhou Aquaculture Service Center (hereinafter referred to as Tongzhou Aquaculture Service Center) obtained the Notice of Project Filing issued by Tongzhou Development and Reform Commission (No.49 [2007] of Beijing Tongzhou Development and Reform Commission) and filed the "Experimental Base Project of Ornamental Fish Culture". On October 22nd, Tongzhou Aquaculture Service Center obtained the Construction Project Planning Permit (2007 G < T > J Zi No.0176) for the "Ornamental Fish Breeding Experimental Base Project", and approved the construction contents as follows: 1#, 2# and 3# breeding experimental sheds, 4# product packaging workshop and 5# product fine packaging workshop, with a total construction area of 5 single buildings.

On June 4th, 2008, Tongzhou Aquaculture Service Center obtained the Notice of Project Filing issued by Tongzhou District Development and Reform Commission (Jing Tongzhou Development and Reform Bureau [2008] No.30) to put on record the construction project of ornamental fish competition hall. On September 4th, Tongzhou Aquaculture Service Center obtained the Construction Project Planning Permit (2008 G < T > J Zi No.0133) for the "Ornamental Fish Competition Hall Project", and approved the construction contents as follows: Ornamental Fish Competition Hall, a single building with a construction scale of 11,870.31 square meters.

Figure 2 Schematic diagram of the approval of the above-ground housing planning on the incident land

2. Land rental construction

Since 2007, Tongzhou Aquaculture Farm has signed six lease agreements with Longhao Company, Beijing Hemei Yudu Trading Co., Ltd., Beijing Meitianhuayi Trading Co., Ltd. (divided into two leases), Beijing Yongshun Zhouzhou Food Co., Ltd. and Liu Yongming personally, and leased 6 plots of land with an area of about 223 mu. Since then, the leased company has undertaken the construction of the "experimental base project of ornamental fish breeding" respectively, and has expanded and rebuilt the building on the incident land several times.

After verification by the planning, housing and construction departments, within the land area of Tongzhou Aquaculture Farm, only six single buildings involved in the "Experimental Base Project for Ornamental Fish Breeding" have gone through the construction project planning permission procedures, while other buildings, including the incident warehouse, have not gone through the relevant planning approval procedures, and have not gone through the construction permission procedures, and the total housing area without the approval procedures is about 151,968.52 square meters.

(four) the construction of the incident warehouse

On June 28th, 2007, Tongzhou Aquaculture Farm signed the Cooperation Agreement with Longhao Company, which stipulated that Tongzhou Aquaculture Farm would provide about 16,650 square meters of land for construction, and be responsible for reporting all kinds of approval procedures. Longhao Company is responsible for the planning and design of the project, and bears all the costs of the project construction. The lease term is 30 years, and the rent is 100,000 yuan/year.

After leasing the land, Longhao Company invested in the construction of the 4# product packaging workshop and the 5# product fine packaging workshop of the "experimental base project of ornamental fish culture", with a total area of about 2,700 square meters. Subsequently, after partially filling the fish pits, Longhao Company successively built workshops, warehouses, office buildings and other buildings, which were successively completed in 2008, with a total construction area of about 6,000 square meters, without obtaining relevant planning approval and construction permit procedures.

(5) Rental and renovation of the incident warehouse.

At the end of 2008, Longhao Company leased the warehouse to Beijing Shichangyuan Trading Co., Ltd. to store pet food. In December 2020, the warehouse was left vacant after it was emptied.

On March 6, 2021, Longhao Company leased a building with an area of 4,741.5 square meters to Boyujie Company (including 1,000 square meters of the West Campus building of Longhao Company, 3,669.5 square meters of warehouse and 72 square meters of frontispiece House). The Lease Contract stated that the leased property had no room cost and was planned, and the lease term was 12 years.

On April 1, 2021, Boyujie Company and Youliang Company signed the Project Contract of Zhangjiawan Cold Storage Project in Tongzhou District, with a total project cost of 2.3 million yuan and a construction area of about 3,283 square meters. The construction content is to transform the original warehouse into a cold storage; The contract time limit for a project is that all the equipment and related accessories will arrive before April 20th, and the installation and debugging will be completed before May 20th.

Subsequently, Wan Mile, the legal representative of Youliang Company, negotiated and cooperated with Chen Peng (individual), the construction contractor, and Chen Peng arranged personnel to be responsible for the reconstruction of the cold storage. Since April 6th, 2021, Chen Peng has hired Huang Bao, Li Fuqiang, Liu Yugang, Gao Weipu and other 10 people to enter the site for construction (during the construction period, Chen Peng paid the fees on a daily basis, and no relevant contract was signed). At the time of the incident, the project was under construction and had not yet been put into use.

Two, the accident, emergency rescue, fire property loss statistics

(1) The course of the accident

On the morning of May 9, 2021, the construction contractor Chen Pengxin purchased a Yongheng brand 315 welding machine and arranged for Li Fuqiang, Huang Bao, Liu Yugang and Gao Weipu to work in the mezzanine above the cold storage. At about 13: 42, the worker Yuan Shicheng transported the extruded board into the cold storage and found that the ground of the east cold storage was on fire. At 13: 44, three workers working outdoors entered the cold storage with fire extinguishers, and the fire was not controlled. The surrounding surveillance video showed that from 13: 44: 09 to 13: 45: 20, a large amount of smoke was ejected from the cold storage doors in the middle and west, and the fire spread from east to west for about 5 minutes. During the period, six people ran out of the cold storage.

(2) Emergency rescue of accidents

At 13: 45 on May 9, 2021, after receiving the fire alarm, the 119 Combat Command Center of the Municipal Fire and Rescue Corps quickly dispatched the full-time headquarters of the corps and detachment, 11 fire and rescue stations, 32 fire engines and 129 officers and men to the scene for disposal, and synchronously linked the public security, emergency, garden, Jinghuan Company and other departments and units and 10 water sprinklers, and used 4 large excavators to arrive at the scene for coordinated disposal to demolish and clean up the accident site. At 14: 35, the open flame was extinguished, and the fire area was more than 3,000 square meters. After the large excavator cleaned up the scene of the accident, three people (Li Fuqiang, Huang Bao and Liu Yugang) who were buried by the building were found on the west side of the incident warehouse, and they were confirmed dead by 120 people.

(3) Statistics on fire property losses

After the fire broke out, the fire rescue agency carried out loss statistics according to the requirements of the Regulations on Fire Accident Investigation and the Statistical Method of Fire Loss. According to the declaration of the direct property loss of the parties, the direct property loss of this fire was 3,090,700 yuan.

Third, the cause and nature of the accident

The accident investigation team obtained relevant qualification documents, accident-related documentary evidence and physical evidence according to law; Fire-fighting and rescue institutions conducted an inquest on the fire scene, carried out tests, inspections and appraisals, and investigated and inquired the relevant personnel involved in the accident, found out the cause of the fire accident and identified the nature of the accident.

(A) the direct cause

Comprehensive on-site inspection, video analysis, investigation and inquiry, etc., the public security organs comprehensively ruled out the suspicion of intentional arson causing fire.

1. On-site inspection. Due to the use of large machinery to dismantle the warehouse during the search and rescue of trapped people, some evidence on the scene was lost. After on-site investigation, a burned electric welding machine, a large number of covered electrode and electric wires with fire melting marks were found on the ground in the south side of the east warehouse. The fire spread from east to west, and the burning degree at the top of the east warehouse was heavier than other parts. The fire rescue agency determined that the fire site was located on the ground in the south of Dongku.

2. Ask for information. It is understood that there is no construction plan for the cold storage reconstruction project, and Chen Peng arranged personnel to carry out the operation. Welding operations have been carried out in the mezzanine of the warehouse and the ground of the cold storage, and liquefied petroleum gas cylinders and oxygen cylinders have been stored in the warehouse. The wires and lighting iodine tungsten lamp used in the site are temporarily set by Chen Peng, and there is a switch box at the mezzanine of the warehouse.

3. Identify the test situation. Tested by the National Construction Engineering Quality Supervision and Inspection Center, the extruded board and polyurethane insulation board used in the reconstruction of cold storage did not meet the requirements of B2(E) and were flammable materials. Through the simulation test, the slag dropped by electric welding can quickly ignite the sandwich between extruded board and polyurethane thermal insulation library board. At the same time, the short circuit of wires and the long-term baking in iodine tungsten lamp also have the possibility of igniting the extruded board.

The fire rescue agency determined that the fire site of this fire accident was located at the ground in the south-central part of the cold storage on the east side of the west yard of Longhao Company; Combined with the field experiment and inspection and identification, it is determined that the fire is caused by the ignition of thermal insulation materials during construction.

(2) Indirect causes

1. Illegal operation. The construction contractor does not go through the formalities for examination and approval of hot work, and does not take corresponding fire safety measures, and uses naked fire in places with fire danger; Youliang Company subcontracts its contracted cold storage construction project to individuals who do not have the corresponding construction qualifications for cold storage projects; After Boyujie Company rented the warehouse of Longhao Company, it entrusted the cold storage project to a company without design qualification for design, and illegally built the cold storage.

2. Illegal construction and illegal rental. After leasing the land allocated by state-owned industries, the enterprises involved illegally built and rented more than 6,000 square meters of buildings without obtaining the relevant planning approval and building construction permit; The relevant government departments failed to inspect the illegal construction within their jurisdiction, lacked effective supervision over the illegal construction behavior of the enterprises involved, failed to take effective measures to stop it, and failed to investigate and deal with the problem of no construction project planning permit in the burning building in time.

3. The investigation and management of potential safety hazards is not in place. Relevant government departments failed to supervise and guide subordinate units and functional departments to perform their duties, failed to establish a ledger for hidden dangers investigation and rectification, and the situation of renting houses and subletting tenants of the enterprises involved was unclear, and no situation of rebuilding cold storage in the incident warehouse and existing fire safety hazards were found; The inspection of fire control and safety production organized by the local government is not in place.

(3) Nature of the accident

In view of the above analysis, according to the provisions of relevant national laws and regulations, the accident investigation team determined that the major fire accident was a liability accident.

Iv. Suggestions on handling the relevant responsible personnel and responsible units of the accident.

(1) Persons who propose to be investigated for criminal responsibility.

1. Jiang Changzheng, the legal representative of Boyujie Company, failed to verify the qualification of the constructor and report the construction to relevant departments; Failing to supervise the on-site construction in place, failing to organize the formulation of fire fighting and emergency evacuation plans in line with the actual situation of the unit, failing to organize fire prevention inspection, failing to organize workers to conduct fire drills and necessary pre-job training, failing to sign a safety responsibility letter, violating the relevant provisions of Code for Design of Cold Storage, Safety Regulations for Cold Storage and Regulations on Fire Safety Management of Government Organs, Organizations, Enterprises and Institutions, and being directly responsible for the accident, Tongzhou District People’s Procuratorate was suspected of serious accident crime in June 2021.

2. Ten thousand miles, the legal representative of Youliang Company, knowing that his company does not have the construction qualification to rebuild the cold storage, still contracted to rebuild the cold storage project; Failing to report the construction to the relevant departments, failing to review the qualifications of workers, failing to report the certificate of hot work, and failing to equip security officers; The Tongzhou District People’s Procuratorate approved the arrest on June 17, 2021 for failing to conduct systematic safety training, signing labor contracts and safety production responsibility letters, violating the Code for Design of Cold Stores, Safety Regulations for Cold Stores, Regulations on Fire Safety Management of Government Organizations, Enterprises and Institutions and the People’s Republic of China (PRC) Fire Protection Law, and being directly responsible for the accident.

3. Chen Peng, the person in charge of on-site construction, failed to give safety education to the workers and signed a safety agreement; Knowing that there were potential safety hazards in the construction site, Tongzhou District People’s Procuratorate approved the arrest on June 17, 2021 for failing to rectify and set up safety supervisors, violating the relevant provisions of People’s Republic of China (PRC) Fire Protection Law and Welding and Cutting Safety, and being directly responsible for the accident.

(two) accountability personnel and units

1. Zhang Chunliang, Deputy Secretary of the Agriculture Working Committee of the District Committee and Deputy Director of the Agriculture and Rural Bureau, gave admonitions.

2. Yang Wenxin, from August 2016 to August 2021, served as a member of the Party Committee and deputy mayor of Zhangjiawan Town, Tongzhou District. He is currently the deputy director of the Medical Insurance Bureau of Tongzhou District, and gave him a warning.

3. Rong Jun, deputy director, section chief and first-level chief clerk of Zhangjiawan Town Ping ‘an Construction Office, was given administrative warning.

4. Mindlin, from November 2010 to August 2012, served as the deputy captain of Zhangjiawan Town Urban Management Law Enforcement Team (presided over the work). He is currently the captain of Liyuan Town Urban Management Law Enforcement Team, the director of Liyuan Town Comprehensive Management Office and the first-level chief clerk, and was given a government warning.

5. Zhang Baohua, from October 2015 to August 2021, served as the head of Tongzhou District Aquatic Technology Extension Station (also the head of Tongzhou Aquatic Farm), and retired in August 2021, giving him a serious warning within the party.

In addition, in view of the fact that the property right unit of the incident plot is a subordinate unit of Tongzhou District Agricultural and Rural Bureau, and there are a large number of buildings that have not obtained the relevant planning approval procedures, the District Supervision Committee of Tongzhou District Commission for Discipline Inspection issued a work reminder letter to Tongzhou District Agricultural and Rural Bureau, requesting it to further intensify its work, comprehensively find out the housing construction situation of the plot where the incident occurred, and pay close attention to the investigation and rectification of illegal construction.

(3) Units that have been given administrative punishment.

1. Boyujie Company failed to formulate and implement the provisions of fire safety management measures and operating procedures, and its behavior violated the provisions of the Measures for the Supervision and Administration of Fire Safety Responsibility in Beijing, and it was responsible for the fire accident, and the fire rescue agency gave it an administrative penalty of 10,000 yuan.

2. You Leng Company’s illegal hot work shall be given an administrative penalty of 10,000 yuan by the fire rescue agency according to law.

V. Suggestions on accident rectification and preventive measures

The accident investigation team put forward the following rectification measures and suggestions for the problems exposed by the accident:

(a) strictly implement the main responsibility of enterprises. Longhao Company and Tongzhou Aquaculture Farm should strictly abide by the laws, regulations and standards related to fire safety management, implement "one warehouse and one policy" refined management for existing factories and warehouses, and implement post responsibilities and fire safety management systems; To strengthen the fire safety protection and inspection of key parts, equipped with necessary fire-fighting facilities and fire-fighting equipment, to ensure the fire safety of warehouses, workshops, office buildings and other places; It is necessary to strengthen fire education and training, strengthen the examination and approval and management of hot work, and enhance the fire safety awareness and emergency response ability of employees. At the same time, it is necessary to do a good job in various safety management during the demolition of illegal construction to prevent all kinds of safety accidents.

(two) comprehensive investigation and management of fire safety hazards. All relevant departments, governments at all levels and units should carry out special actions on fire safety law enforcement inspection of warehouses, focusing on rectifying illegal operations, illegal construction, illegal hot work and welding; It is necessary to guide enterprises and institutions to self-examine and correct hidden dangers around them. For those who cannot rectify themselves, organize full-time and part-time forces to carry out investigation and inspection, sort out problems, establish ledgers, clarify rectification responsibilities, measures and time limits, carry out multi-departmental joint law enforcement and comprehensive rectification, and strengthen publicity, education and training, regularly track and review hidden dangers of write-offs, and prevent problems from rebounding and hidden dangers from resurfacing. For the hidden dangers that are difficult to rectify at the moment, it is necessary to implement targeted management and nursing measures, supervise and supervise, and promote rectification.

(three) to crack down on illegal construction and illegal rental behavior. Tongzhou district government should vigorously develop the industrial format that conforms to the positioning of Beijing’s sub-center, and actively promote the work of resolving and rectifying and promoting promotion; It is necessary to urge the local township governments to intensify the verification and disposal of houses that have not been approved for construction, identify and investigate them according to laws and regulations, and complete the demolition of unlicensed houses in stages and batches by means of self-demolition, whistle-blowing and joint law enforcement. All districts and units in the city should intensify the crackdown on illegal construction and illegal renting of factories and warehouses, and establish a long-term mechanism and regional cooperation and cooperation mechanism to prevent factories and warehouses that do not have formalities and safety conditions from being rented and subletted repeatedly.

Compilation Shu Wang Cong

Editor: Wang Duoyu

Typesetting Shu Shui Chengwen

The long-term vision for artificial intelligence (AI) is to develop AI systems that can make major scientific discoveries, learn autonomously, and acquire knowledge autonomously.

虽然“AI 科学家”（AI scientist）这一概念还只是一种理想化的愿景，但基于智能体（agent）的AI技术的发展，为开发能够进行对话、具备反思学习和推理能力的AI智能体（AI agent）铺平了道路，这些AI智能体能够协调大型语言模型（LLM）、机器学习（ML）工具、实验平台，甚至是它们的组合。

近日，哈佛大学医学院 Marinka Zitnik实验室（高尚华博士为第一作者）在 Cell 期刊发表了题为：Empowering biomedical discovery with AI agents 的文章，系统介绍了利用 AI 智能体（AI agent）推动生物医学发现。

该文章提出了这样一个观点——“AI 科学家”可以被由人类、大语言模型、机器学习模型及其他工具（例如实验平台）组成的复合AI系统所支持的 AI 智能体（AI agent）所实现。

我们将“AI 科学家”设想为具备批判性学习和推理能力的系统，它们能够通过协作智能体整合 AI 模型和生物医学工具，并与实验平台相结合，从而为生物医学研究提供助力。

生物医学 AI 智能体不是将人类排除在发现过程之外，而是将人类的创造力和专业知识与 AI 分析大量数据、探索假设空间和执行重复性任务的能力相结合。AI 智能体将能够熟练完成各种任务，规划发现工作流程并进行自我评估，以识别并解决其知识中的差距。这些智能体使用大语言模型（LLM）和生成式模型来实现结构化记忆以进行持续学习，并使用机器学习工具将科学知识、生物学原理和理论融入其中。AI 智能体可以影响从虚拟细胞模拟、可编程的表型控制到细胞回路设计以及开发新疗法等各个领域。

The first author, Dr. Gao Shanghua, received his doctorate from Nankai University and is now a postdoctoral researcher at Harvard Medical School

The complexity of biology requires the flexibility to break down complex problems into executable tasks. AI agents can break down problems into manageable sub-tasks, which are then solved by AI agents with specific functions and integrate scientific knowledge. In the near future, AI agents can accelerate the discovery process by making workflows faster and more resource-efficient.

Leveraging AI agents to advance biomedical research

The continuous development and application of data-driven models

AI agents in the biomedical field – from LLM-based AI agents to multi-agent systems that integrate AI models, tools, and physical devices

Level of autonomy of AI agents

Cases of autonomy levels for AI agents in genetics, cell biology, and chemical biology

Core terms of machine learning

Key modules in AI agents: perception, interaction, reasoning, and memory modules

Components of a biomedical AI agent

The challenges of AI agents in biomedical discovery

AI agents can improve the efficiency of routine tasks, automate repetitive processes, and analyze large datasets to outperform current human-driven efforts in scale and accuracy. This automation allows for continuous, high-throughput research that human researchers cannot conduct individually at the same scale or speed.

Looking to the future, AI agents can provide insights beyond what traditional machine learning can achieve by making predictions across temporal and spatial scales before obtaining experimental measurements at both temporal and spatial scales. Ultimately, AI agents may help uncover new patterns of behavior in biological systems.

Original link:

https://www.cell.com/cell/fulltext/S0092-8674 (24) 01070-5

Read the original text

　　The Spring Festival is approaching, and the population is flowing in large numbers, so the number of people who work in cities and return home to visit relatives for holidays will increase rapidly. This has also brought severe challenges to the treatment of rural COVID-19.

　　"Grassroots medical and health institutions have undertaken a large number of tasks of first diagnosis of patients and classified management of key populations." On January 14th, Nie Chunlei, director of the Department of Primary Health and Health in National Health Commission, said that there was an imbalance in medical resources between urban and rural areas, with obvious differences, and health service resources in rural areas were relatively insufficient. "Grassroots village doctors urgently need to master the knowledge and skills of Covid-19 infection diagnosis, severe early warning and treatment, especially the use of antibiotics, hormones and small molecule drugs, so that patients can be effectively treated."

　　On January 11th, the General Practice Branch of Chinese Medical Association, together with several branches, issued the "Guidelines for Diagnosis, Treatment and Service of Infections in novel coronavirus (First Edition)" (hereinafter referred to as the "Guidelines"), which elaborated on diagnosis, clinical classification, identification, treatment and treatment of severe cases.

　　How to warn of moderate and severe diseases?

　　"For the grassroots, the evaluation of COVID-19’s diagnosis and clinical typing is more important, and it is also the whole of the diagnosis and treatment strategy." Wu Hao, the correspondent of the Guide and dean of the School of General Practice and Continuing Education of Capital Medical University, said.

　　In the evaluation of patients’ clinical typing, Wu Hao said that the majority of grassroots village doctors need to pay special attention, and the evaluation of vital signs can be carried out through a simple "four-piece set" of body temperature, respiration, heart rate and blood pressure; In the measurement of finger oxygen saturation, due to the low outdoor temperature in winter, the village doctor found that the patient’s limbs or skin were cold, and its oxygen saturation value may be less than 93%, but this does not mean that the patient is at risk, and it is necessary to judge by observing whether the lips are purple and dry.

　　Imaging examination can be based on chest X-ray or CT. If there is pneumonia in COVID-19, most of it occurs in the lower lungs. If there is no CT in rural medical institutions, you can auscultate whether the patient’s lower lungs are accompanied by wet rales (if there is, CT examination is not necessary); Instead of taking X-ray chest film, you need to pay attention to the patient’s posterior and anterior and lateral films, and sometimes you can see some exudative and inflammatory lesions. Although the X-ray chest film may miss the diagnosis, if the chest film shows pneumonia, the actual situation of the patient will be more serious.

　　"What needs to be repeatedly emphasized is the early warning of severe illness." Wu Hao said that the patient’s three situations indicate that it is very dangerous and may progress to severe illness. First, moderate and severe dyspnea occurred, including (meeting one of the following conditions) heart rate greater than 120 beats/min, breathing frequency greater than 30 beats/min, and breathing with an auxiliary ventilator (pay attention if the patient cannot speak a whole sentence during the consultation); Second, the oxygen saturation is lower than 93%; In addition, if the patient has chest pain, falls, changes of consciousness, low blood pressure, decreased urine output, severe vomiting or diarrhea, etc., we should also consider severe warning.

　　Zhang Wenhong, director of the Department of Infectious Diseases of Huashan Hospital affiliated to Fudan University, said during the training that after the implementation of the "Class B and Class B Management" policy, it is crucial for grassroots doctors to master the transformation from Chinese diseases to severe diseases in the process of normalizing COVID-19 treatment. In particular, the clinical classification of patients was adjusted in the "novel coronavirus Infection Diagnosis and Treatment Program (Trial Tenth Edition)", instead of ordinary type, it was medium. "Light and medium-sized should be treated at the grassroots level. Therefore, the grassroots should prevent medium-sized to heavy-duty, and heavy patients need to be referred in time. "

　　Zhang Wenhong said that in the clinical early warning of severe illness, one indicator has changed and it is necessary to be alert to the deterioration of the patient’s condition, that is, the patient is "hypoxic after activity; After slight activity, the oxygen saturation value is less than 94%, which can make the patient walk back and forth in the corridor. If his CRP(C-reactive protein), lactic acid and other indicators are normal, it means that the oxygen saturation value has decreased, which is also a signal of the progress of the disease.

　　How to use hormones and antibiotics?

　　Is it really effective for rural doctors to use the four-piece set of "antiviral+antibiotic+hormone+antipyretic"?

　　Wu Hao explained that, in fact, the elderly people in rural areas were not treated in time after onset, and there was malnutrition. When he went to the clinic for medical treatment, he might be in the acute pneumonia period, and even had a bacterial infection. At this time, the village doctor will give hormone and antibiotic treatment, and the effect will be more obvious.

　　Regarding whether antiviral drugs can be used for more than 7 days, Wu Hao said that the time of viremia is usually 7 days. The reason why antiviral drugs are prescribed to be used within 5 days of onset is because the earlier they are used, the greater the benefit, which also takes into account the incubation period of 1 ~ 2 days. "For the elderly and frail patients, the process of virus clearance is slow. At this time, even if the illness lasts for more than 7 days, it will still be effective to continue using antiviral drugs."

　　Wu Hao further said that the use of antibiotics should also avoid blindness and should be judged with reference to the patient’s indications. For example, if the patient coughs dry or coughs white sputum, or has less sputum in the early stage, this is a viral infection; If the patient has pus or coughs yellow sputum, it is generally a bacterial infection. If the village doctor doesn’t have the above-mentioned accurate detection means, he can write it all in combination with the patient’s situation, that is, his family members are infected and have flu symptoms, and he also has lung symptoms, which is definitely viral pneumonia, but if his family members don’t have it, it is the possibility of community-acquired pneumonia.

　　In order to facilitate the operation of primary doctors, the "Simplified Edition" published on January 4th referred to the "four-step" treatment of COVID-19 at the primary level: general treatment, oral small molecular antiviral drugs, glucocorticoid, oxygen therapy and respiratory support.

　　Therefore, Zhang Wenhong emphasized that glucocorticoid should be used with great caution. It is suitable for COVID-19 patients with high-risk factors (older, with medium-sized clinical manifestations and evidence of disease progression). At this time, low-dose and short-term corticosteroids can be given. "Specific usage, you can use dexamethasone or prednisone, 4 ~ 6 tablets a day, eat for 3 days. Within 72 hours, the patient will face a turning point. If the patient gets better quickly, it will be reduced to 2-3 tablets and taken for another 3 days. If it is relieved later, either stop taking the medicine or use another tablet for 3-4 days. If the patient progresses to severe illness, he needs to be hospitalized for observation, and the dosage of hormones can also be increased, and the treatment plan for severe patients can be started later. "

　　"On the one hand, an early British clinical study showed that the daily use of 6 mg dexamethasone in large-scale hospitalized patients in COVID-19 can reduce the mortality rate; On the other hand, our team also gives patients low doses of hormones in the early stage of severe illness, which can greatly reduce the intubation rate of patients and reduce the mortality rate. " Zhang Wenhong said.

　　The Guide stipulates that glucocorticoid can be used for patients with early onset in the community, such as high-risk factors such as basic diseases and advanced age, or medium-sized patients who need oxygen therapy, after evaluating the contraindications of hormone use.

　　Zhang Wenhong said that "prone position ventilation treatment" for COVID-19 patients can be operated regardless of the resources of rural medical institutions, and it is suitable for medium-sized patients with severe high-risk factors and rapid progress. This is also recommended by many respiratory and critical care experts.

　　"When the patient is lying on his back, the heart and lungs are under certain pressure, and there will be problems in the proportion of ventilation blood flow. After prone, the pressure on the heart and lungs is reduced, the proportion of ventilation blood flow will be more balanced, and the physiological diseases related to inflammation of patients will also get better. " Li Yingchuan, an expert in critical care medicine and vice president of Shanghai Tenth People’s Hospital, explained to reporters earlier.

Liu Xianbao at Work

CCTV News:21 years ago, Liu Xianbao graduated from high school. At that time, his sister was not married, his brother was unemployed at home, and his old father worked hard to keep the house alone. In order to reduce the burden on his family, Liu Xianbao came to Shanghai alone from his hometown of Wuhu, Anhui Province and became an air conditioner installer.

When he first arrived in Shanghai, Liu Xianbao rode his bicycle to install air conditioners in every house before dawn every day, and worked 15 hours a day. A year later, he realized that it is difficult to get any big gains by working hard, and only by learning excellent technology can he break into a brand-new world.

As a result, Liu Xianbao began to spend most of his savings on his studies. After work, he finds time to participate in various skills training. In 1998, Liu Xianbao was admitted to an air-conditioning company, and he jumped from a junior maintenance worker to a senior technical backbone within one year. He also accepted four apprentices as an excellent old teacher.

However, Liu Xianbao always holds such an idea in his heart: to be his own brand, run his own company and do something.

In 2002, with rich work experience, Liu Xianbao opened his own maintenance shop. Unlike ordinary repair shops, Liu Xianbao’s shop is not in the bustling street, but is wrapped in the depths of the grocery market by clothing shops and daily necessities shops. Repairing electrical appliances is generally a regular business, and it is the primary task to let residents know and convey their sincerity actively. In addition to excellent maintenance technology, retaining customers depends on a business philosophy different from others. Liu Xianbao made such a sign: free of service charge and only charge for materials.

As a result, the store’s signboard became a hit, and residents in the community took out recorders, radios and remote controls that had been in disrepair for a long time to come to Liu Xianbao for maintenance. For the elderly over 80 years old, he took the initiative to come to help repair. Because the maintenance is all small household appliances, we have not earned any money, but also posted a lot of money.

Although I lost money, I won word of mouth. Liu Xianbao’s maintenance department is getting bigger and bigger, and his public service is getting bigger and bigger.

Liu Xianbao (middle)

In May 2008, Liu Xianbao set up the "Spring Care" service team to help the elderly, and carried out free air-conditioning cleaning and maintenance services for elderly people and disabled families living alone in the community. As long as a phone call is made, Liu Xianbao will immediately dispatch a special person to the door for maintenance. All small household appliances are free, and everyone only charges material fees. Over the years, he has benefited hundreds of thousands of yuan and repaired more than 100,000 home appliances.

Taking care of each other is naturally the concern of the residents. In the hot summer, some residents will send Liu Xianbao an iced drink to quench thirst and dispel summer heat. In the cold winter, some residents will come and give Liu Xianbao a cup of hot water and a greeting.

Now, 43-year-old Liu Xianbao has his own company.Sub-centers have been opened in 11 towns and industrial parks in Minhang District, Shanghai, covering more than 600 communities, and public welfare services have naturally not fallen behind. He rebuilt the old family lines for the solitary, pure old and lonely old families in Jiangchuan Street, and opened the safety files of electricity and gas consumption for the elderly over 60 years old, so as to reduce the risk of fire and gas poisoning in residents’ families.With this love, he found a new neighborhood friendship, a lifelong career and a home for his soul in this city.

"When I was studying, I saw a lot of Shaw House on campus. Later, I learned that these were donated by Mr. Run Run Shaw, who has done a lot for public welfare. I want to be like him. This is my ideal. " Liu Xianbao said. (Source: CCTV Network)

Cumulatively reported more than 170 million doses of COVID-19 vaccine.

By April 13th, 2021, 31 provinces (autonomous regions and municipalities directly under the Central Government) and Xinjiang Production and Construction Corps had reported a total of 175.623 million doses of Covid-19 vaccine.

Recently, National Health Commission held a news briefing, inviting the responsible persons and experts of vaccination to popularize knowledge about vaccination in COVID-19 and answer questions from reporters.

How effective is China’s vaccine in protecting foreign mutant Covid-19? Yin Weidong, chairman of Beijing Kexing Zhongwei Biotechnology Co., Ltd., said that virus variation had been taken into account when developing vaccines. The R&D team has obtained the mutant Covid-19 strains from South Africa and Brazil. Through experiments, it is found that the vaccine in China can effectively neutralize these two strains, presumably playing a protective role.

"It is necessary to promote vaccination in COVID-19 on a large scale and form an immune barrier." Shao Yiming, a researcher at China CDC, analyzed that at present, compared with some countries, the epidemic situation in China has been effectively controlled, and the epidemic situation in COVID-19 outside China is very serious, so China is facing greater pressure to import the epidemic situation. With foreign countries, especially European and American countries, controlling the epidemic through vaccination and strengthening prevention and control, the global mobility will be released, and the risk of our people will increase greatly, because there is a huge immunization gap with foreign countries. We should grasp this window period, vaccinate on a large scale according to the order recommended by the government, and build an immune barrier, so as to effectively resist the risk of imported epidemic.

"From a scientific point of view, it is safe for the elderly to be vaccinated." Shao Yiming said that recent research has collected more and more data on the protection of vaccines for the elderly, and no problems have been found. For the elderly with basic diseases, if the disease is in the onset stage, it is best to communicate with the vaccination doctor before vaccination and follow the arrangement of the vaccination doctor. "After large-scale vaccination, some people have common side effects such as redness, induration and pain at the vaccination site, which is a normal phenomenon of vaccination." Shao Yiming said.

Yin Weidong said that National Medical Products Administration’s conditionally approved COVID-19 vaccine is allowed to be used in people over 18 years old, indicating that people over 60 years old can use it. The company has taken the elderly over 60 years old as the main object of vaccine clinical research, and the research results have been published in The Lancet. The results show that the antibody positive conversion rate of the elderly after vaccination is nearly 100%, which is almost the same as that of other people.

Wang Huaqing, chief expert of immunization program of China CDC, believes that the research shows that cancer patients have poor resistance, and the severe disease rate and mortality rate of COVID-19 are high, so they should take the lead in vaccination. However, due to the effective prevention and control of epidemic situation in China, the risk of infection of such people is extremely low. Before vaccination, whether the tumor patient is in the acute stage of onset can be judged by the vaccination doctor.

Is it necessary for ordinary people to test antibodies after vaccination with Covid-19 vaccine? Andy On, chief physician of the Center for Immunization of China CDC, said that after people are vaccinated, there is no need to do antibody testing. In the clinical trial stage of the vaccine, researchers have already done antibody tests, and only when the vaccine is effective can it pass the tests and finally go on the market. It is not necessary for ordinary people to test again. Antibody detection requires a strict laboratory environment, and ordinary people do it privately, and the results may not be accurate because they do not have the laboratory conditions. (Reporter Shen Shaotie)

Every time the AI news, on February 26th, the market news said that china galaxy and CICC planned to merge through share swap, which is expected to be announced in the next few weeks. In this regard, Xinhua Finance asked the two brokers for verification, and both public relations departments expressed ignorance. The above rumors have been reported many times in 2024, but they were denied by both companies. (Xinhua Finance)

In the automobile industry, there is a term that is not familiar to the public, but enjoys a high reputation in the professional circle, and that is air suspension. In recent years, air suspension, once regarded as the exclusive configuration of luxury cars, is now accelerating to the mass market.

If we trace back to the development of air suspension, this popular trend has been blowing for several years. More and more star models equipped with air suspension are ready to come out, from /L8/L9 to Weilai, Kelp, and now, the guide price of air suspension has dropped to less than 200,000, further promoting the heat of air suspension.

According to the latest statistics of intelligent driving configuration database of Geshi Automobile Research Institute, from January to December, 2024, the sales volume of new cars with standard air suspension in China was about 816,000, and the penetration rate reached 3.6%. In the same period of 2023, the sales volume of new cars with standard air suspension was 564,000, the penetration rate was 2.7%, and the carrying capacity increased by 44.7% year-on-year. It can be predicted that the development speed of air suspension market will continue to accelerate.

On the one hand, the permeability of air suspension is increasing, and its development speed has exceeded market expectations. At the same time, the supporting price of air suspension is also rapidly sinking, which is close to the standard range of about 200,000 yuan. On the other hand, with the increasing market share of air suspension, the competition between domestic suspension and foreign suspension will become more and more fierce.

The breakthrough of technology, the reduction of cost and the rapid growth of market demand have provided a strong impetus for the popularization of air suspension. Then, will the road of "popularization" of air suspension be smoother and smoother?

The pattern is stable, and domestic substitution is just the time.

Judging from the development in 2024, the market structure of air suspension still continues the characteristics of the rise of domestic forces, and the concentration is getting higher and higher. In 2024, local manufacturers accounted for more than 80% of the air suspension market.

In recent years, the air suspension market has shown a highly concentrated competition pattern, and domestic suppliers have opened a lot of gaps with overseas brands by virtue of technological progress and cost advantages. In 2024, the installed capacity of air suspension market exceeded 800,000 sets, among which Konghui Technology ranked first with 335,470 sets of installed capacity, with a market share of 41.3%. Kong Hui Technology’s market penetration in the field of new energy vehicles is particularly prominent, and its technical advantages enable it to provide customized air suspension solutions for car companies to meet the needs of different models.

Top Group followed closely, with an installed capacity of 209,760 sets and a market share of 25.8%. Top Group occupies an important position in the middle and high-end vehicle market through continuous technological innovation and cost control. Its products are not only comparable to imported brands in performance, but also more competitive in price, which promotes the application of air suspension in more models.

Baolong Technology ranked third with an installed capacity of 159,535 sets, with a market share of 19.6%. Baolong Technology has further consolidated its market position with its own research and development capabilities and customer resources. Its air suspension system is excellent in performance, reliability and cost control, especially in the promotion of low-end market.

In contrast, the market share of traditional international suppliers such as Wayback and Continental Group is 7.8% and 5.0% respectively. As an internationally renowned supplier, Weiback mainly serves high-end brand vehicles, while Continental Group is relatively deep in technology accumulation, but slightly conservative in market competition.

From the overall market point of view, the top five suppliers account for nearly 90% of the market share, and the market concentration is getting higher and higher. These leading enterprises rely on their strong R&D strength and market influence to continuously promote the progress of air suspension technology and market expansion. In the future, with the further maturity of technology and the reduction of cost, air suspension system is expected to be applied in more models, further promoting the growth of market demand.

The rise of domestic brands in the air suspension market is not accidental, and there are many key factors behind it.

From the most intuitive point of view, the development of the new force of building cars has given more opportunities to local air suspension suppliers. For example, Lantu Automobile gave Kong Hui tickets, which verified Kong Hui’s technical accumulation for many years; Ideal helps Kong Hui become a qualified supplier of auto parts. These stories are still vivid, and now the cooperation between new power enterprises and domestic air suspension enterprises is getting closer and closer, and both sides grow together.

In addition, domestic brands have made a significant breakthrough in air suspension technology, which is not only equivalent to imported brands in performance, but also excellent in cost control. In 2023 -2024, domestic air suspension experienced two or three iterations, from single cavity to mainstream dual cavity, which led to great changes in the whole product line and significant cost reduction. This cost advantage enables domestic brands to provide air suspension configurations for more low-end models, thus expanding market share.

"Quick response and supply chain stability are also one of the advantages of domestic air suspension enterprises." Wang Lin (pseudonym), a person in the auto parts industry, pointed out that compared with foreign suppliers, domestic brands have more advantages in development cycle and response speed. The development cycle of foreign suppliers is usually longer, while domestic brands can respond to market demand more quickly and provide flexible solutions. In addition, domestic brands have also performed well in the stability of supply chain and can better cope with market fluctuations.

It is imperative for air suspension to get on the bus on a large scale.

From the whole analysis logic point of view, electrification has greatly changed the load-bearing system of automobiles, and the rapid development of new car-making forces has laid the foundation for the high-end brand of automobiles in China. This also means that the popularity of electric vehicles has brought opportunities for the wide application of air suspension.

The sale of electric vehicles is much more, which makes the air suspension widely used; There are more new forces to build cars, which gives local suppliers more opportunities; Only when the brand of China is high-end can it accommodate the cost of air suspension.

The permeability data of air suspension also illustrates some problems. According to the analysis of intelligent driving configuration data of Geshi Automobile Research Institute, from January to December, 2024, the highest monthly penetration rate of air suspension configuration reached about 4.4%, and the monthly supporting capacity exceeded 100,000 sets, entering an explosive growth stage. The carrying capacity gradually increased from 25,000 sets at the beginning of the year to the peak of 76,000 sets in June and 102,000 sets in December, indicating the steady growth of market demand. At the same time, the permeability started from 1.9% in February and rose in fluctuation, reaching 4.5% in June, indicating that the acceptance of air suspension standard in the market is increasing day by day.

We also see that the development of domestic air suspension enterprises is in full swing. For example, in 2024, Baolong Technology announced the number of designated projects as high as 28, involving an amount of over 11 billion yuan. These projects not only demonstrated the technical strength of Baolong Technology, but also laid the foundation for the large-scale application of air suspension.

A series of indications show that the large-scale popularization of air suspension is close at hand. At one time, air suspension was more common in high-end luxury models, such as, and so on, and its high cost made it difficult to widely promote it. However, with the rise of domestic suppliers, the cost of air suspension is significantly reduced, and the price of vehicles equipped with this configuration is also more close to the people.

Taking 2024 as an example, air suspension has been applied in 200,000-yuan models. It is a typical representative, and the starting price of its model equipped with air suspension is only 289,800 yuan. In addition, the starting price of the latest Krypton 001 is 259,000 yuan, and the air suspension can be optional for the entry model. What is more noteworthy is that the dark blue G318 is equipped with an air suspension version, and the starting price is only 199,900 yuan.

"At present, there is an obvious sinking trend of air suspension on new energy vehicles, and it is likely to further drop to 180,000-190,000 in the future." Wang Lin believes that the standard value of air suspension will be lowered, and the possibility of getting on the bus on a large scale is very high.

However, Wang Lin also added his own analysis. From the aspects of quality, design process and overall cost (including maintenance cost), there is limited room for the cost of air suspension to sink further. From the perspective of cost analysis, he pointed out that it is difficult to reduce the cost of even a single-cavity air spring, because the whole air suspension system includes the body and the supply system, such as air pump, air valve, compressor, gas storage tank and sound insulation layer. The development cost of the system has dropped from about 2000 yuan before to about 1800 yuan at present. Unless domestic manufacturers make breakthroughs in core components, it is unlikely that the cost will be further reduced.

In the future, with the further development of technology and the continuous reduction of cost, air suspension is expected to be applied in more models. Therefore, it is predicted in the industry that the overall permeability of air suspension will reach about 15% in 2025. With the development of intelligent suspension technology, air suspension will be combined with more intelligent driving functions to provide consumers with more intelligent and personalized driving experience.

What is the odds of air suspension going out to sea?

When the domestic air suspension market structure is relatively stable, the competition is becoming more and more fierce. Therefore, we have also seen a new trend. With the maturity of domestic air suspension technology and the improvement of market competitiveness, domestic suppliers have begun to look to the international market.

Recently, Baolong Technology received the Notice of Fixed Point from a famous European automobile company, and became a component supplier for its brand-new platform project, Air Supply Unit (ASU) of air suspension system. The life cycle of the project is 7 years, and the total amount exceeds RMB 160 million. It is expected to start mass production in 2027. This indicates that the domestic air suspension technology has been recognized by the international market, laying a foundation for the further expansion of domestic suppliers in the international market.

However, we also need to see the challenge of domestic air suspension forces going out to sea. Judging from the overall market structure, foreign air suspension forces are not in a strong position in the China market. For example, although Kangdi has built a factory in Jiangsu to promote localization, its speed is slow; Weiback, on the other hand, relies entirely on imports and has not yet set up a factory in China. However, they are in a strong position in the international market.

In the international market, the field of air suspension has long been monopolized by a few foreign giants. Condi (affiliated to Continental Group) and Weiback are two giants in the global market, and they have absolute advantages in technology and market share. Japanese manufacturers also mainly rely on the products of Condi and Weiback in the luxury car field, and almost no domestic products are used.

Domestic air suspension enterprises also clearly realize that the road to sea is not smooth sailing. As Chao Wang, general manager of Baolong Science and Technology Supply Chain Development Center, said, when China enterprises enter the international market, they are often restricted by many factors. Whether an enterprise can win a project order depends not only on whether the product is excellent and whether the price is competitive, but also on many other complex factors that may affect the cost control, delivery ability and cooperation experience with customers.

Wang Chao also added, "Maybe after we go, we can still build a certain advantage through a period of adaptation, but this advantage may not be so obvious compared with our advantage in China."

To this end, Baolong Technology needs to solve the possible challenges from the perspective of supply chain. In 2024, Baolong Technology established a new department supply chain development center. In addition to optimizing the procurement strategy, another important task of the new department is to strengthen the overseas supply chain.

In fact, Baolong Technology started earlier in overseas layout, and had previously set up some factories overseas. Today, Baolong plans to build more purely overseas supply chains. Chao Wang said that although Baolong had some overseas factories before, the original supply chain was still dominated by China supply chain. Now, due to geopolitical problems, many customers demand the localization of supply chain, so the new department will help overseas factories to establish a purely overseas supply chain.

However, in his view, compared with foreign-funded enterprises, China enterprises still have a comparative advantage. "For example, in terms of efficiency, if a China supplier can complete a project in six months at home, a foreign investor in China will complete it in nine to twelve months, and if it goes to Europe, a China supplier may complete it in nine months, and a foreign investor may complete it in 12 to fifteen months. This step difference also exists. Of course, this data description is not for specific projects, but mainly for an image description. "

Despite the challenges, Chao Wang is full of confidence in the future development. He believes that in the next few years, China suppliers will gradually catch up. "Generally speaking, China suppliers will be able to provide products with advanced technology, good quality and competitive cost in the future."

With the continuous progress of technology and the further reduction of cost, domestic suppliers are expected to occupy a more important share in the international market and contribute more to the global development of air suspension.

Gai Shi Xiao Ji

Air suspension is moving from high-end to mass, which is driven by many factors, such as technological breakthrough, cost reduction, market demand growth and the rise of domestic suppliers.

With strong R&D strength and cost advantage, domestic suppliers have gained significant market share in the domestic market and started to expand into the international market. With the further development of technology and the continuous expansion of the market, air suspension is expected to become the choice of more ordinary consumers and inject new impetus into the intelligent and comfortable development of the automobile industry.

Perhaps, in the near future, air suspension will not only become the standard in the domestic automobile market, but also occupy an important position in the global market.

[car home Taiyuan Preferential Promotion Channel] is carrying out price reduction promotion activities in Taiyuan, with the highest preferential amount of 114,900 yuan and the lowest starting price of 325,000 yuan. Friends who want to start with this luxury car may wish to seize the time to click "Check the car price" in the quotation form and strive for higher discounts.

BMW 5 Series (imported) is elegant in design, with classic kidney-shaped air intake grille on the front face and sharp headlight group, which shows the perfect combination of luxury and sports. The body lines are smooth, outlining a dynamic and powerful outline. The overall style is fashionable and steady, showing the unique charm of BMW brand.

BMW 5 Series (imported) has a body size of 5060*1900*1515mm and a wheelbase of 2995mm, which provides spacious interior space for passengers. The side lines of the car are smooth and dynamic, with a 19-inch rim, which adopts a fashionable multi-spoke design and perfectly blends with the overall shape of the car body. The front and rear tyre size are both 245/45 R19, which not only improves the handling performance of the vehicle, but also enhances the visual effect.

The interior design of BMW 5 Series (imported) is elegant and luxurious. The center console is equipped with a 14.9-inch high-definition touch screen, which integrates multimedia system, navigation, telephone, air conditioning and other functions, and supports voice recognition control, bringing more convenient and intelligent experience. The steering wheel is made of leather, which provides electric up-and-down and forward-and-backward adjustment functions and is flexible to operate. The front row is equipped with two Type-C charging interfaces, and the rear row has four USB/Type-C interfaces to meet the charging needs of passengers. In addition, the front seats are equipped with heating and ventilation functions to improve the ride comfort. The front and rear seats, backrest, height, leg rest and lumbar support can be adjusted, and 4-way electric adjustment is supported to ensure the driver’s comfort. The seat is made of imitation leather, full of luxury, and the rear seats can also be laid down in proportion, providing more space flexibility.

BMW 5 Series (imported) is equipped with a 2.0T turbocharged engine, with a power output of 190 HP, a maximum power of 140kW and a maximum torque of 310 N m.. The car is equipped with an 8-speed automatic manual transmission to ensure smooth power transmission.

The owner of car home said: "The appearance is my favorite, not only because it is an imported version, but because all BMW models are sporty, and the designer’s aesthetic for young people is still in place. At least many friends around me drive BMWs, and they especially like its sporty design. The new model adds a luminous air intake grille, which not only looks good after lighting at night, but also has a very high recognition. "

　　In his important speech at the symposium on cyber security and informatization, General Secretary of the Supreme Leader pointed out that the Internet is not a place of extra-legality, and it is necessary to strengthen the governance of cyberspace in accordance with the law in an attitude of being responsible to the society and the people, so as to create a clean cyberspace for the majority of netizens, especially the majority of teenagers. The country can’t be cured, and the network can’t be ruined. At present, cyberspace has become a new channel for information dissemination, a new space for production and life, and a new territory for state governance. For the sustainable and healthy development of cyberspace, we must use the rule of law thinking and methods to explore the way of governing the network by pipe network, strengthen network legislation, strictly enforce the law on the network, guide netizens to respect the law and abide by the law, and comprehensively promote the rule of law in cyberspace.

　　Strengthen the thinking of the rule of law and give play to the basic role of the rule of law in guiding network behavior.

　　"The impermanence is strong, impermanence is weak. Those who serve the law are strong and the country is weak. " To comprehensively promote the rule of law, we must strengthen the rule of law. Cyberspace is virtual, but the subject of using the network is realistic. Cyberspace is an extension of the real society, interwoven and influenced by real social relations, interest relations and social roles. Cyberspace is clear and the ecology is good, which is in line with the interests of the people. Cyberspace is smoky and ecological deterioration, which is not in the interests of the people. No one wants to live in a space full of falsehood, fraud, attack, abuse, terror, pornography and violence. At the same time, network security affects the whole body, which has a certain impact on national politics, economy, culture, society and national defense security. All these require us to bring Internet management into the track of rule of law, comprehensively promote the rule of law in cyberspace, and let the Internet run healthily on the track of rule of law.

　　Without strict rules, there will be no orderly cyberspace. As an effective way to standardize and institutionalize cyberspace, the rule of law is a common practice all over the world. The United States, Britain, Russia and other countries have successively formulated and promulgated cyberspace strategies, plans, policies and regulations, and strengthened the management of Internet content. The United States has clearly defined the Internet world as an area that needs to be controlled as much as the real world, promulgated nearly 200 relevant laws and regulations, and passed the Cyber Security Act of 2015, giving American Internet service providers unprecedented network supervision and management rights. The EU has adopted the Directive on Network and Information Security, which provides basic legal protection for the development of digital economy in the EU. Canada and Brazil respectively promulgated the Federal Law on Information, Informatization and Data Protection and the Network Civil Law as the basic laws in the Internet field.

　　The rule of law thinking is the ideological basis of the rule of law in cyberspace. Under the background of ruling the country by law in an all-round way, we must strengthen the thinking of the rule of law, attach importance to the role of law in regulating and regulating, make decisions and act according to law, promote the deepening reform and innovative development of cyberspace according to law, strengthen scientific legislation, strictly enforce the law, and ensure the correct implementation of the law. It is necessary to define the bottom line of network behavior, the red line of cyberspace, and the high-voltage lines that violate laws and regulations, so as to provide guidelines for operators to build and run networks, provide rules for netizens to use the Internet, and provide basis for regulators to manage the network through pipe networks, thus building a rational, orderly and dynamic cyberspace.

　　Strengthen scientific legislation and build a standardized internet by relying on a strict legal network

　　"If good laws are established in the world, then the world will be ruled; If a good law is established in a country, then a country will govern. " Law is the heavy weapon of governing the country, and good law is the premise of good governance. Since China’s full access to the Internet in 1994, China has formulated more than 70 laws, regulations and normative documents related to the Internet, especially since the 18th National Congress of the Communist Party of China. The National Security Law, the Criminal Law Amendment (IX) and the Anti-Terrorism Law have been promulgated one after another, and relevant regulations and normative documents such as Internet finance, advertising management, online publishing, search, live broadcasting and application procedures have been implemented one after another. There is a basic basis for pipe network, network operation and network use according to law, which has played an important role in promoting the healthy development of the Internet and safeguarding national security, public interests and the legitimate rights and interests of citizens, legal persons and other organizations. In particular, the promulgation of "Network Security Law" indicates that Socialism with Chinese characteristics’s cyberspace laws and regulations system has taken shape. However, the current network legal system construction is not suitable for the rapid development of information technology and the increasingly complex network security situation. Strengthening cyberspace legislation is still an important and urgent task.

　　The rule of law system in cyberspace is an important part of the rule of law system in Socialism with Chinese characteristics, so we must insist on legislation first and give play to the leading and promoting role of legislation. To promote the rule of law in cyberspace, the first thing is to improve the cyberspace laws and regulations system with scientific content, strict procedures, complete supporting facilities and orderly operation. Pay more attention to overall planning and top-level design, pay more attention to exploring and following the scientific laws of network governance, pay more attention to improving the systematicness, pertinence and effectiveness of Internet legislation, and make Internet legislation interconnected, coordinated and organically unified. We should constantly speed up the formulation and promulgation of basic legislation such as e-commerce, personal information protection and e-government. Improve laws and regulations on Internet information services, network protection for minors, security protection of key information infrastructure, Internet news information services, online audio-visual programs, online culture, and financial information services. Improve judicial interpretation and policy interpretation, promote the extension of existing laws to the Internet, and regulate network behavior.

　　Strengthen network law enforcement to ensure that laws and regulations are implemented.

　　"It is not difficult to legislate, but it is difficult to enforce the law." The vitality of law lies in implementation, and the authority of law also lies in implementation. Governing the network by pipe network is an important supervision and management law enforcement activity. Without strict law enforcement, it will be difficult to implement the rule of law. The Fourth Plenary Session of the 18th CPC Central Committee put forward clear requirements for the construction of the rule of law in the Internet field. In order to strengthen network law enforcement, the State Council authorized the National Internet Information Office to be responsible for the national Internet information content management and law enforcement. In recent years, network law enforcement departments have continuously intensified their efforts to crack down on illegal information and behaviors, investigated and dealt with a number of influential typical cases, increased the exposure and warning of illegal websites, and significantly improved the standardization level of network law enforcement.

　　To ensure the correct implementation of network laws, we need to continue to deepen the reform of network administrative law enforcement system and mechanism. It is necessary to improve the basis of law enforcement on the Internet, promote the reform of the network law enforcement system, integrate the administrative law enforcement resources of law enforcement departments and network information departments at all levels involved in network management, and promote comprehensive law enforcement and administrative law enforcement supervision on the Internet in accordance with the principles of reducing levels, integrating teams and improving efficiency, so as to fundamentally avoid problems such as inconsistent standards, unsynchronized actions and inconsistent results brought about by "Jiulong Water Control" and multi-department law enforcement. It is necessary to improve the network law enforcement procedures, clarify the specific operational procedures, and implement the network administrative law enforcement publicity system, the whole process of law enforcement record system and the legal review system of major network law enforcement decisions in accordance with the reform deployment and direction. Establish and improve the benchmark system of administrative discretion, refine and quantify the benchmark of network law enforcement discretion, and standardize the scope, type and range of discretion. Fully implement the network administrative law enforcement responsibility system and strictly implement the accountability mechanism.

　　"Law, if you commit a crime, you will do it; Order, only do not return. " It is necessary to strictly implement the Cyber Security Law, the Anti-Terrorism Law, the Decision of the Standing Committee of the National People’s Congress on Strengthening the Protection of Network Information and other laws and regulations to prevent problems such as passive law enforcement, lax law enforcement, and inadequate law enforcement. Network operators and related subjects who violate laws and regulations shall be given warnings and ordered to make corrections according to law until they are shut down, so as to avoid legal provisions being shelved, becoming "scarecrows" and having a broken window effect. It is necessary to severely crack down on the use of the Internet to advocate the overthrow of state power, incite religious extremism, propagate ethnic separatist ideas, and instigate violent terrorist activities. We will intensify the punishment of illegal crimes such as fraud, theft, drug trafficking, spreading obscenity and pornography, infringing on personal privacy and intellectual property rights through the Internet. Strictly guard against cyber crimes, especially new cyber crimes, and safeguard the interests of the people and social harmony and stability. Establish and improve the information sharing mechanism, and actively participate in the international joint action against Internet crimes.

　　Strengthen respect for laws and regulations, and guide websites to run networks according to law and netizens to surf the Internet according to law.

　　"If the law stands on the top, the custom will follow.". At present, there are 731 million netizens and 4.82 million websites in China. Cyberspace has become the common spiritual home of hundreds of millions of people. Spreading positive energy through the network and creating a clear cyberspace have become the conscious actions of many websites and hundreds of millions of netizens. At the same time, some phenomena that deviate from the socialist core values, unilaterally pursue clicks and forwards, play "edge ball" and even touch the legal bottom line occur from time to time. We must earnestly implement the main responsibility of Internet enterprises to run the network according to law, strengthen industry self-discipline, establish self-discipline mechanism and industry norms, comprehensively use various means to standardize enterprise behavior and manage employees, and ensure that market operations do not exceed the rule of law. Strengthen the construction of network integrity, establish and improve the website integrity evaluation mechanism, improve the law-abiding credit records of online social organizations, websites and netizens, improve the law-abiding integrity reward mechanism and the disciplinary mechanism for illegal and untrustworthy behaviors, and gradually establish a punishment and withdrawal mechanism according to law.

　　The authority of law comes from the people’s inner support and sincere belief. It is necessary to follow the law of network communication, comprehensively use all kinds of new media technologies and applications to carry out legal popularization activities, and vigorously carry forward the spirit of socialist rule of law. Carry out legal service activities such as online legal consultation and legal aid, guide members of society to consciously safeguard the legal order in cyberspace, use legal weapons to protect their legitimate rights and interests, and resolutely fight against cybercrime. Adhere to the combination of ruling the Internet by law and ruling the Internet by virtue, carry forward the socialist core values, carry forward the excellent Chinese traditional culture, play the role of moral education, nourish the spirit of the rule of law with morality, guide netizens to form rational and civilized moral habits and moral concepts, and form a good atmosphere for striving to be "good netizens in China".

　　(The author is an associate professor at the Law Department of the National School of Administration)

1905 movie network news On October 22nd, the 28th China Golden Rooster and Hundred Flowers Film Festival and the press conference of the 32nd Golden Rooster Award for Chinese films were held in Beijing, at which the nomination list of this year’s Golden Rooster Award was announced.

This year’s Golden Rooster Awards will select a total of 19 awards. Dying to Survive won eight nominations, including "Best Feature Film", "Best Director’s First Novel", "Best Screenplay" and "Best Actor", leading the nomination list. Later We, Auld Lang Syne, The Wandering Earth’s Legend of the Demon Cat each received five nominations, and Guo Zhaoguan received four nominations.

Main Visual Poster of the 28th China Golden Rooster and Hundred Flowers Film Festival

Six films including Gutian bugle, Forever, Later Us, Operation Red Sea, Dying to Survive and The Wandering Earth will compete for the "Best Feature Film"; Wang Jingchun (Forever), Yang Taiyi (Crossing Zhaoguan), Duan Long (Blizzard Coming), Xú Zhēng (Dying to Survive), Tumen (Old Beast) and Fu Dalong (Entering Beijing) will compete for "Best Actor". Best Actress will be produced in Ma Yili (Finding You), Bai Baihe (Ma Ge is a City), Yongmei (Forever), Zhou Dongyu (Later Us), Zhao Xiaoli (Singing Alive) and Yao Chen (Send me to Qingyun).

Main Visual Poster of the 28th China Golden Rooster and Hundred Flowers Film Festival

The films participating in this Golden Rooster Award are: feature films, children’s films, science and education films, documentaries, opera film, and art films reviewed and approved by the State Film Bureau from May 16, 2017 to June 30, 2019. The Golden Rooster Award registration started on May 5th this year and ended on June 30th. A total of 277 films were registered, 110 of which passed the primary election.

The 28th China Golden Rooster and Hundred Flowers Film Festival will be held in Xiamen, Fujian Province from November 19th to November 23rd. On the evening of the 23rd, the 32nd Golden Rooster Award for Chinese Film will be awarded at Xiamen International Convention and Exhibition Center.

The complete nomination list of the jury is as follows:

Best feature film (nomination)

Best Small and Medium-budget Feature Film (Nomination)

Guo Zhao Guan

Best Children’s Film (Nomination)

Take the train to Beijing

Best opera film (Nominated)

Buyi woman

White Snake

Han Yuniang

Best science and education film (nomination)

The story of potatoes

Big fish control water

The Great Green Wall

Panda growing up

Best documentary(nomination)

Hello Beijing

"Drama Memory &mdash; &mdash; Mulan

Marx

The age of struggle

Diary of the Tibetan antelope king &mdash; &mdash; Polar tracking

Best art film(nomination)

C9 Home

New Big Head Son and Small Head Dad 3: Russian Adventures

The best playwright(nomination)

Zou Jingzhi ()　

Ah Mei and Wang Xiaoshuai (Forever)

Yuan Yuan, Shing-Ming Ho, Pan Mi, An Wei, Rene Liu (Later Us)

Han Jianv, Zhong Wei, Muye Wen (Dying to Survive)

Bao Jingjing ()

Teng Congcong ()

best director(nomination)

Wang Xiaoshuai (Auld Lang Syne)

Lu Le ()

Lin Chaoxian (Operation Red Sea)

Guo Fan (The Wandering Earth)

Dong Yue ()

Huo Meng ()

Best directorial debut(nomination)

Wang Lina ()

Muye Wen (Dying to Survive)

Rene Liu (Later Us)

Peng Li (Puppy Bottle)

Teng Congcong ("Send me to Qingyun")

best actor(nomination)

Wang Jingchun (Liu Yaojun in Forever)

Yang Taiyi (Li Fuchang in Guo Zhao Guan)

Duan Long (Guowei Yu in "Blizzard is Coming")

Xu Zheng (Dying to Survive Zhongshi Cheng Yong)

Tumen (middle decoration Lao Yang)

Fu Dalong (Yue Jiu in Entering the Capital)

best actress(nomination)

Ma Yili (Sun Fang in Finding You)

Bai Baihe (middle decoration Mei Xiaoou)

Yong Mei (Wang Liyun in Auld Lang Syne)

Zhou Dongyu (Fang Xiaoxiao in "Later Us")

Zhao Xiaoli (Zhao Li in Singing Alive)

Yao Chen (played by Sheng Nan in "Send me to Qingyun")

Best Supporting Actor(nomination)

Eric Wang (Dying to Survive Zhong Shi Lu Benefited)

WangZhifei (Zhu De in Gutian bugle)

Tian Zhuangzhuang (Lin Fu in Later Us)

Li Yunhu (Li Yining in Guo Zhao Guan)

Xin Baiqing (middle decoration Li Bai)

Zhang Yu (Dying to Survive middle decoration Peng Hao (yellow hair))

Best supporting actress(nomination)

Wu Yufang (Liang Meizhi in "Send me to Qingyun")

Kylie Binur Rehemituli (played by Kylie in The First Parting)

Xu Xing (played by Aunt Niu in 72 Hours in the School District)

Jiang Luxia (Operation Red Sea Zhong Shi Tong Li)

Best cinematography(nomination)

Liu Yin (The Wandering Earth)

Li Yong (The First Parting)

Zhao Xiaoding ()

Geritu ()

Cao Yu (Legend of the Demon Cat)

Nianping Zeng ("Ma Ge is a City")

Best recording(nomination)

Danrong Wang, Zhu Yanfeng, Liu Xu (The Wandering Earth)

Wang Gang and Liu Xiaosha ()

Long Xiaozhu and Zhang Jinyan (Blizzard Coming)

Liu Jia (Legend of the Demon Cat)

Ji Chenggang and Wang Yingang (Gutian bugle)

Guo Ming ()

Best art(nomination)

Ma Guangrong (Shadow)

Liu Qiang (Blizzard Coming)

Li Miao (Dying to Survive)

Song Xiaojie (Animal World)

Gao ‘ang (The Wandering Earth)

Tu Nan and Lu Wei (The Legend of the Demon Cat)

Best music(nomination)

Liu Sijun ("Going to Beijing by Train")

Guan Xia and Yang Fan (Gui Xiang Street)

Zou Ye (Breaking the Door)

Ju Wenpei (Gutian bugle)

Shu Nan (Entering Beijing)

Dou Wei (Chunjiang Water Heating)

Best editing(nomination)

Bai Yuxia and Tan Yukun (Flying Life)

Chi-Leung Kwong, Bai Huiling and Wang Ran (Flash Girl)

Zhu Liyun (Entering Beijing)

Zhu Lin (Dying to Survive)

Li Dianshi (The Legend of the Demon Cat)

Ching-Song Liao and Wu Fang (Puppy Bottle)