Among the 18 million new cancer cases and 9.6 million cancer deaths worldwide, China has 3.804 million new cases and 2.296 million deaths. This means that China accounts for 21 of every 100 new cancer patients in the world; China accounts for 23 out of every 100 cancer deaths in the world.

　　In the face of cancer, doctors are the hope of patients, and drugs are the weapons of doctors.

　　Recently, the first bevacizumab bio-similar drug in China was approved for marketing, which will improve the accessibility of this kind of drug and provide a new choice for the treatment of domestic patients. Some people call 2019 the outbreak year of biologically similar drugs. In November this year, the first adalimumab bio-similar drug in China was approved for listing; In February this year, the first domestic biological similar drug Rituximab was approved for listing & HELIP; … So, what kind of anticancer drugs do monoclonal antibodies belong to, and what are biologically similar drugs? Today, Xiaobian will take you to know.

　　Q: What are the common anticancer drugs?

　　A: Clinically, it is customary to divide anticancer drugs into cytotoxic anticancer drugs and non-cytotoxic anticancer drugs.

　　1. Cytotoxic anticancer drugs

　　Cytotoxic anticancer drugs are chemotherapy drugs that we often say, and their main functions are to inhibit the proliferation of cancer cells and induce their apoptosis, thus eliminating cancer cells.

　　2. Non-cytotoxic anticancer drugs

　　Common non-cytotoxic anticancer drugs include hormone drugs, targeted drugs and immunotherapy drugs. In recent years, there has been a great breakthrough in the development of this kind of drugs. Next, we will focus on the common non-cytotoxic anticancer drugs.

　　Hormone drugs

　　Some hormone-dependent cancers, such as breast cancer, prostate cancer, thyroid cancer, cervical cancer, etc., are related to hormone imbalance. Therefore, the application of certain hormones or their antagonists can change the hormone balance, thus inhibiting the growth of dependent cancer cells, such as tamoxifen and exemestane, which are clinically used in breast cancer.

　　Targeted drugs

　　Targeted drugs can act on the unique signal pathway of cancer cells, killing cancer cells, but little or no damage to normal cells.

　　In the treatment of cancer, it should be said that targeted drug therapy is a precise treatment based on accurate diagnosis. By accurately finding the target of disease treatment and accurately monitoring the disease state and treatment process, we can finally achieve precise treatment for different patients and diseases in different States, and achieve the purpose of improving the treatment effect of diseases. Bevacizumab mentioned at the beginning is one of the targeted drugs.

　　Immunotherapy drugs

　　Immune cell therapy technology is to achieve therapeutic effect by regulating the precise immune response of human immune T cells to cancer cells. For example, the monoclonal antibody drug PD-1/PD-L1, an immune detection point, can specifically bind to PD-L1 on cancer cells to inhibit its expression, so that the inhibited T cells can recover their recognition function to cancer cells and achieve the anti-cancer effect.

　　In addition, some traditional Chinese medicines can also directly or indirectly damage cancer cells by regulating the immune function of the body, so as to prolong the survival time of patients and improve the quality of life.

　　Q: What are biologically similar drugs?

　　A: Biomimetic drugs refer to therapeutic biological products that are similar to the original drug (reference drug) that has been approved for registration in terms of quality, safety and effectiveness.

　　Q: What’s the difference between similar drugs and generic drugs?

　　A: Biomimetic drugs, also known as biosimilars, are biological drugs (including vaccines, blood and blood components, somatic cells, gene therapy, tissues, recombinant therapeutic proteins, etc.) similar to the approved original drugs. In principle, the amino acid sequence of candidate drugs for biological analogues should be the same as that of the original drug (reference drug).

　　Q: How to use anticancer drugs rationally?

　　A: Pay attention to the following three points when using anticancer drugs well:

　　1. Diagnose before taking medicine.

　　All clinical patients who use anticancer drugs must be confirmed by histopathology before using them. If targeted drugs are used for treatment, genetic testing must be carried out in advance.

　　2. Use drugs under the guidance of professional doctors and pharmacists.

　　For cancer patients with definite diagnosis, if it is standardized treatment, doctors and pharmacists need to choose appropriate drugs, definite usage and reasonable period for treatment according to the recommendations of the guidelines; If it is experimental treatment, doctors and pharmacists need to follow the relevant provisions of medical ethics, formulate a perfect clinical research plan for patients, and choose the corresponding drugs for treatment.

　　3. Pay attention to drug-related adverse reactionsshould do

　　During the use of anticancer drugs, patients should closely monitor their physical condition and report adverse reactions to doctors and doctors in time, which is very important for completing the treatment course and improving the quality of life.

　　Q: What do you think about the side effects of taking anticancer drugs?

　　A: In recent years, anticancer drugs have emerged in an endless stream, and their curative effects have been greatly improved. However, the selectivity of many anticancer drugs is still not high. While killing cancer cells, it will inevitably cause damage to normal cells, which is also the main reason that hinders their efficacy.

　　The most common side effects of anticancer drugs include: myelosuppression such as neutropenia, anemia and bleeding; Nausea, vomiting, constipation, diarrhea and other digestive system toxic manifestations; Hepatotoxicity and nephrotoxicity occurred.

　　Q: What should we think about the side effects of taking anticancer drugs?

　　A: If there are no suitable targeted drugs for some cancer cells, or because of certain conditions, patients must choose chemotherapy schemes with greater toxic and side effects. Under the above circumstances, doctors need to predict the side effects of anticancer drugs as soon as possible and deal with them effectively, so as to choose the best treatment scheme for patients.

　　Compared with traditional chemotherapy schemes, targeted therapy and immunotherapy have fewer toxic and side effects, and are new choices for patients.

　　With the development of precision medicine, we have reason to believe that the side effects of anticancer drugs will become smaller and smaller, and the effective rate of disease treatment and the survival time of patients will be greatly prolonged. (Content Synthesis: National Medical Products Administration official website Information Release)

1905 movie network news A few days ago, her role in Dead Waiter 3: Deadpool and Best Friend was exposed, and she will play Cassandra Nova Xavier, the evil twin sister of Professor X.

In the cartoon, Cassandra, after copying the DNA of "Professor X" charles xavier, has the telepathic ability equivalent to that of charles xavier, which makes her have telepathic transmission ability, and can suspend and manipulate living and inanimate objects, and to some extent, manipulate energy through psionics. At the same time, she can copy and manipulate the DNA of all beings, and use it to build a body for herself, so that she can pretend to be them to deceive the gene scanner.

Emma Colin once said that she is not a big fan of Marvel Comics, but the stories, characters and even highlights in Marvel Comics’s films have always attracted her. Therefore, she was very excited to play a villain in Marvel Comics’s film.

The film Dead Waiter 3: Deadpool and His Best Friend will be released in North America on July 26th.

Author: Xiangya Medical College of Central South University-Wang Xuemei

The development process of red blood cell system in bone marrow is pluripotent stem cells → pluripotent stem cells → primitive red blood cells → early erythrocytes → middle erythrocytes → late erythrocytes → reticulocytes → mature erythrocytes. Today we are going to talk about reticulocytes.

　

reticulocyte

Reticulocyte is a transitional cell from enucleated late erythrocytes to mature erythrocytes. It is named reticulocyte because of the remaining basophilic substances such as ribosomes and ribonucleic acid in its cytoplasm. After living staining with Brilliant Tar Blue or Neomethylene Blue, blue or blue-green reticular structure can be seen in its cytoplasm. This kind of cell belongs to immature red blood cells, which remain in the bone marrow for a certain period of time before being released into the blood stream. Therefore, the number of reticulocytes in bone marrow is not only higher than that in peripheral blood, but also naive, which is a sensitive index to judge the inhibition and recovery of hematopoietic function in bone marrow.

Clinical significance of reticulocyte parameters

Differential diagnosis of anemia

The combination of absolute reticulocyte count (RET﹟) and immature reticulocyte index (IFR) is helpful to judge the type of anemia.

Table 1. Differential diagnosis of anemia by RET combined with IRF [1-3]

Notes:

(1) The results only explain the experimental research samples;

(2) Immature reticulocyte index (IFR) is defined as the ratio of immature or immature reticulocytes to total reticulocytes. The closer to maturity, the lower the fluorescence intensity of reticulocytes, and the larger the volume of immature reticulocytes. According to their light scattering characteristics, they are mainly high and medium fluorescence reticulocytes with high fluorescence intensity and high residual RNA content.

Monitoring of radiotherapy and chemotherapy

The dynamic observation of reticulocyte can guide the clinical adjustment of treatment plan in time and avoid serious bone marrow suppression. In the process of cancer chemotherapy, 1RF is a very sensitive index to reflect bone marrow suppression and recovery. In the stage of complete bone marrow suppression, IRF can be reduced to zero. After receiving radiotherapy and chemotherapy, if bone marrow suppression occurs, the IFR will first decrease and then the reticulocyte value will decrease. If the bone marrow begins to recover after stopping radiotherapy and chemotherapy, IFR will also increase first, and then the reticulocyte value will increase. Immature reticulocyte (IRF) is an important sensitive index to evaluate the curative effect of anemia drugs, especially in chronic renal failure or acquired immunodeficiency disease.

Monitoring of bone marrow transplantation

The increase of peripheral blood granulocyte count is the basis for early monitoring after transplantation, but the absolute value of granulocyte may be affected by simultaneous infection and transplant rejection. In addition, preventive platelet transfusion will also affect the monitoring of platelet manufacturing ability in the early stage of transplantation. Therefore, both are not ideal. Reticulocyte parameter is an independent parameter to detect hematopoietic recovery of bone marrow, which is usually not related to transplantation complications.

Ret-he (reticulocyte hemoglobin)

It is used to diagnose iron metabolism disorder anemia and detect the state of iron storage in the body. This parameter is of great value for the diagnosis and treatment of anemia caused by functional iron deficiency, and can monitor the effect of EPO and iron treatment. Ret-He is decreased in functional iron deficiency caused by stored iron loss, which is a typical iron deficiency anemia and can be treated with iron agent (orally). When functional iron deficiency is accompanied by RET-He decline in iron-rich state, iron injection and EPO should be used for treatment.

references

Jia Lianling, Ou Hongling, Huan Wang, Zhao Haijiao, Li Meng, Wang Xinru. Diagnostic value of new reticulocyte parameters for anemia [J].

Xu Guizhu, Ronghua Qiu. Clinical significance of reticulocyte and red blood cell parameters in differential diagnosis of thalassemia and iron deficiency anemia in pregnant women [J].

Chen Min, Xiaowei Liu. Clinical value of reticulocyte parameters in diagnosis of anemia [J].

This article was originally written by the Voice of Inspection, please indicate the source.

Editor: Green is about to drip

Review: Chenchen

In the summer of 2009, Pizza Hut cancelled its salad self-service in China chain stores, but foreign media seemed to have just recovered. The British "Post Online" news website analyzed and reported on the 29th of this month why Pizza Hut’s buffet salad was withdrawn in China, and listed in detail the case that Chinese became a "salad engineer" when he arrived at Pizza Hut, and concluded that "Pizza Hut could not afford to play after meeting Chinese". For the whimsy of China diners, foreign netizens also have different views. Some netizens envy and hate, "My mother Mia, it looks so good, I will do the same!" Some netizens criticized, "I don’t think we should waste food. It is said that there are still some children in China who don’t have enough to eat … …”

Foreign netizens hotly discuss Chinese Pizza Hut "Salad Tower" to force it to cancel salad self-service.

The following is the full text of the report:

A few years ago, Pizza Hut closed the salad buffet in China, and the official statement was that it was part of the menu reform. But many people think that the real reason is that the Pizza Hut diners in China can always make the Big Mac salad tower, so the cunning China diners came up with this idea.

Because compared with the generous Pizza Hut in Europe and America, the Pizza Hut in China only allows diners to help themselves with salads at the salad counter at one time. Therefore, diners in China certainly won’t waste this opportunity, which is also the only one. They invented the "salad tower" and piled up all kinds of fruits and vegetables in order to get more salads at one time.

China Diners’ "Masterpieces"

As a result, this kind of "salad tower" has become a trend. Many people post their "salad tower" on the Internet to show off, so everyone wants to surpass others and build a higher Pizza Hut "salad tower". Those "salad engineers" also shared their experience of stacking on the Internet. For example, if you want to stack the "salad tower" very high, you must first put the crispy foods such as carrots and cucumbers on the base and lay a good foundation.

Because Pizza Hut is positioned as a high-end restaurant in Asia, not a cheap fast food restaurant, when Pizza Hut restaurant in China announced that it would no longer set up its own salad service in China, people took it for granted that the "salad tower" was the cause.

Of course, after learning the bad news, Chinese seems to be more keen on building a "salad tower" to make up for the regret of the accumulation of colorless lacquers.

Kotakure website commented that Pizza Hut still kept some salad self-service in China’s capital, but this kind of play has gone out.

Foreign netizens also have different views on the whimsy of China diners. The following are excerpts from foreign netizens’ comments:

Pizza Hut "Salad Tower" — — Pure handmade

My mother Mia, it’s so awesome. It looks good. I’m going to do the same!

I think it’s better not to waste food. It is said that there are still some children in China who don’t have enough to eat … … Forget it. Forget it.

Well, it’s really incredible!

Aren’t they afraid that eating all these at once will hurt their stomachs?

Wonderful Pizza Hut "Salad Tower"

I’m not surprised at this at all. I have lived in China for three years, and sometimes when I have brunch in a five-star hotel on weekends, I am really shocked every time. Chinese always fills the plate with food, as if it were their last meal. Whether it’s salad, caviar or dessert, Chinese can eat all the food you can name, and he eats a lot.

I remember that when people went to Pizza Hut for dinner a few years ago, they had to pay extra for salad. At that time, I always put salad in a bowl, because I could take more. I think I didn’t know I was dwarfed until I went to the East. I still like the way diners in China do, and I have learned a lot from them. I often go to Pizza Hut after returning to China, and then pile up salads to make all kinds of "salad towers", and I enjoy the feeling that employees and other guests stare at me. I think I am awesome!

Chinese has never eaten western food. You see that China is full of Pizza Hut, McDonald’s and KFC, and supermarkets are full of Tesco and Wal-Mart. Have you ever seen China-branded restaurants or other chain stores in Britain and America?

God-like existence — — Pizza Hut Salad Tower

I think Chinese’s "salad tower" is the greed of a few people that has damaged the interests of many people.

This looks very unsightly. I’m curious when was the last time they ate, and why did they keep stuffing food into their mouths?

I think only people who like salad very much can take so much at a time, otherwise it will be so heavy that all the food below will be crushed, and I feel disgusting.

I have a very simple way. Salad service is charged by weight. Let’s see if they will still take so much!

Although it is short, it is full of Pizza Hut "salad tower"

I can’t figure it out. In all Pizza Huts in the United States, the food in the salad bar is full, and few people take it … … Except, of course, Pizza Hut near Los Angeles Airport.

Real men eat potatoes and meat, not salads!

Ok, this really shocked me, but the salad in Pizza Hut tastes ok, so why put so much!

Well, they really have time to do this. When it’s done, the pizza will get cold.

Teach you how to build Pizza Hut "Salad Tower" by hand.

Original post address: British Post Online, Longteng.com.

　　Cyber hackers, who committed crimes in groups, were sentenced for making and spreading obscene articles on the Internet for profit, and committed crimes again during probation. These are the characteristics of the cases involving Li and Chen in Lishui, Zhejiang Province, among the six cases of trafficking in pornography publicly notified by the National Office for Combating Pornography today. In fact, judging from the facts of the six cases, each case is shocking in terms of both the means of committing crimes and the degree of harm.

　　The person in charge of the national office of "eliminating pornography and illegal publications" pointed out that these six cases are typical cases in which the national office of "eliminating pornography and illegal publications" chose "net" and "protecting seedlings" to investigate and deal with important progress, which has been completed or the investigation has ended.

　　Rent an overseas server to commit crimes in groups.

　　The first case reported by the national office of "eliminating pornography and illegal publications" was a case in which Li and Chen in Lishui, Zhejiang Province made and disseminated obscene articles for profit.

　　According to reports, in November 2018, according to the report of the masses, the Economic Development Zone Branch of Lishui Public Security Bureau filed a case to investigate the case and set up a task force. At present, the case has been ascertained, and eight suspects have been arrested, including Li and Chen, the principals who directed and produced obscene videos. At the same time, more than 100,000 obscene videos were seized, and the amount involved was more than 7 million yuan.

　　According to the national office of "eliminating pornography and illegal publications", from 2016 to 2017, Li and Chen Moumou filmed obscene videos for sale in the name of "Kuramoto C, underwear brother, and 91 principal". Since October 2017, Li and Chen, Chen Mou, Lin and others have rented overseas servers and set up 91B1 obscene websites to make profits by selling members and recharging VIP. Zhao, Zhu and others filmed obscene videos and uploaded them to the network disk, and then sold them through the 91B1 website. In this case, more than 100,000 people were purchased, distributed in various places and overseas areas. At the end of 2018, the task force successively arrested four principals, including Li and Chen, in Guangdong and Hebei. Recently, the task force captured four people, including Zhao and Zhu, in Shandong, Hunan and Guangxi.

　　The national office of "eliminating pornography and illegal publications" said that the suspect in this case has a high reputation on the Internet. In 2016, the criminal suspect Zhao became a "great god" by making and selling his own obscene videos on the Internet in the name of "91 Daige", and his videos were found on almost all Chinese obscene websites.

　　Not only that, the main suspect Li is a hacker and was sentenced for hacking cases; Zhao was sentenced for making and spreading obscene articles on the Internet for profit, and is still on probation. "Different from previous cases, the suspects who filmed obscene videos in this case did not fight alone, but committed crimes in groups." The National Office of "Combating Pornography and Illegal Publications" pointed out that in 91B1 website, there are as many as 20 suspects who are engaged in making obscene videos for profit, including a female criminal suspect in Taiwan Province.

　　26 people who imitated Tik Tok to sell pornography were detained.

　　26 people were criminally detained and 110,000 obscene short videos were seized. Today, the National Office of "Combating Pornography and Illegal Publications" reported the case of "Fast Fairy" short video App spreading obscene articles for profit in Shenzhen, Guangdong Province, saying that the short video platform involving pornography in this case was huge.

　　The National Office for Combating Pornography said that in this case, the "Fast Fairy" App claimed to be an "adult version of Tik Tok". Since it was launched in October 2018, its pages and browsing methods have all imitated "Tik Tok", but only obscene and pornographic short videos have been disseminated.

　　To make matters worse, operators have also introduced incentives. As of the time of the incident, there are nearly 3 million registered users, and more than 1,000 users have uploaded obscene videos. Operating gangs have made a profit of over 10 million yuan by charging gambling sites advertising fees.

　　The national office of "eliminating pornography and illegal publications" said that on March 23 this year, Longgang police began to collect nets in 15 cities across the country and arrested 26 suspects. At present, the App has been seized according to law, and the case is still being further explored.

　　50,000 cross-border agent development members

　　Judging from the situation reported by the national office of "eliminating pornography and illegal publications", the case of "June 29" spreading obscene articles for profit in Guigang, Guangxi was also extremely bad.

　　"In June 2018, the public security organs of Guigang City inspected and found that a netizen in the jurisdiction was suspected of spreading obscene video clues and filed a case for investigation." According to reports, this netizen is the general agent and customer service of "Pymai" obscene video website.

　　The National Office for Combating Pornography pointed out that this website management team has a clear division of labor and a strict organization. The gang has more than 10 main members and more than 100 offline agents, involving 20 provinces and countries such as Malaysia and Singapore. Through the combination of website and WeChat group, the gang has developed more than 50,000 members, involving more than 13 million yuan. At the end of 2018, the task force launched a unified arrest operation, arresting 16 suspects one after another, and 14 people including Jia Mou were arrested according to law, detaining more than 50,000 pornographic videos stored in the server, and destroying 3 studios used to disseminate obscene pornographic information. In February this year, this case was transferred to the procuratorate for review and prosecution.

　　Hundreds of female anchors engage in obscene performances.

　　In the case of Shanghai Changning "Cherry Live" App spreading obscene articles, the public security organs found that hundreds of female anchors were engaged in obscene performances.

　　According to the introduction of the National Office for Combating Pornography, in January 2019, the network inspection of Changning Branch of Shanghai Public Security Bureau found that there were some pornographic Apps in Apple’s mobile App store, among which the "Cherry Live" app was the most popular. Finally, it was verified that there were hundreds of female anchors engaged in obscene performances and spreading obscene videos in this App, with tens of thousands of viewers and millions of funds involved.

　　After a lot of work such as preliminary investigation and fixed evidence, the task force of Changning Public Security Bureau went to Chongqing, Hunan, Guangdong and other places to arrest. At present, 43 people involved in the case have been successfully arrested, all of whom have been criminally detained, and the case is under further investigation.

　　The server develops 3000 members abroad.

　　According to the national "anti-vice and pornography" office, in August 2018, the public security organs of Lu’ an City, Anhui Province found in their work that the website named "Zhengtai Community" disseminated obscene videos and pictures.

　　After further investigation, it was verified that this website was founded by Qi, with a server abroad and more than 3,000 registered members. There are more than 2,000 obscene videos and more than 8,000 pictures on the website, some of which involve minors. The public security organs arrested three suspects, including Qi. In March 2019, the case was prosecuted by the procuratorate.

　　"cute girl" spreads child pornography videos

　　The profit-making case of spreading child pornography videos in the "Mengmeizi" forum in Liaocheng, Shandong Province is the sixth case notified by the National Office for Combating Pornography and Illegal Publications.

　　"In August 2018, according to the national ‘ Eradicate pornography and illegal publications ’ The office turned to clues, and the public security organs of Liaocheng City and yanggu county City quickly carried out investigations, cracked the case and arrested the main suspect Liu. " The National Office for Combating Pornography said that since July 2017, Liu rented an overseas server through a network technology company in Lianyungang, Jiangsu Province, and established a "cute girl" forum to sell and disseminate child pornography videos, with a total of more than 130,000 members, including more than 400 paid members, with a profit of more than 70,000 yuan. At present, this case has been handed over to the procuratorate for review and prosecution.

　　Obscene and pornographic information is the focus of the crackdown

　　The person in charge of the national office of "eliminating pornography and illegal publications" pointed out that obscene pornographic information is the focus of the current crackdown. In the first quarter of this year, the "anti-pornography and illegal publications" department strictly rectified the dissemination of obscene and pornographic information by using live webcasts, short videos, "two micro-ends" and other platforms, and resolutely investigated and dealt with a large number of cases of online pornography, pornography and pornography.

　　The person in charge said that since the beginning of this year, the departments of "eliminating pornography and illegal publications" in various places have taken the initiative to maintain the high-pressure situation of cracking down on illegal and criminal activities involving pornography, and promoted the in-depth development of special actions such as "net work" and "protecting seedlings" through investigating cases. Among them, from January to March, a total of 1,079 cases of "cracking down on pornography and illegal publications" were filed nationwide, including more than 130 criminal cases and 541 cases involving the Internet.

　　Legal Network Beijing April 18 th

Original title:Hard enough, not only a new milestone in China’s science fiction movies.— — A Brief Comment on Wandering Earth 2, a New Year movie.

Wen Zhen Cheng Bo (Professor, Doctoral Supervisor and Vice President of Shanghai Film Academy, Shanghai University)

New film viewpoint

Special fund support for the development of national film industry

How does the prequel become a sequel?The experience of a series of films tells us that each film should be a new "this one", not just a predecessor or sequel to a certain film, and should not be the so-called "second life, second life and third life" rhythm.

Why can science fiction be hard-core?Characters and stories must first stand up; Then the audio-visual realism and spectacle should be enough, and it is better if we can use new technologies and platforms; Furthermore, whether we can leap from "fantasy" to "thought", the discussion on ideology and philosophy lies in audio-visual and stories, but it is not closed, which can inspire questioning and reflection.

If we say that the "window opening" and "ceiling" of China’s sci-fi movies in 2019 have been going around for a few years, and the film market has changed due to the epidemic, it is difficult for domestic sci-fi movies to produce any hardcore masterpieces. By the Spring Festival in 2023, Wandering Earth 2, the second part of this series of movies, tells the story of The Wandering Earth’s prequel, but it has "broken the door" beyond the hardcore level of its predecessor.

Storytelling, Wandering Earth 2 shows how The Wandering Earth’s basic world outlook structure came into being, and two crises before Jupiter crisis — — The attack in 2044 and the moon crisis in 2058.

This is a step in the process from the present to the future, and it is a phased state from the near future to the farther. The "Wandering Earth" project is a grand human epic spanning 2,500 years. How it happened and how it was possible, and the credibility logic needs to be shown by movies.

On the surface, the crisis in 2044 is how the mainstream "Wandering Earth" faction responded to the "terrorist attack" of the opposition "Digital Life" faction. This is a routine of spy war and thrilling action movies, but at the same time, it has completed the personal construction of Liu Peiqiang and Han Duoduo (The Wandering Earth’s grandfather named his sister Han Duoduo to commemorate his daughter who died of illness), and the "space elevator" for those who face the wall in "Three-body".

At the same time, the appearance of Tu Hengyu leads to the clue of supercomputer artificial intelligence 550W. The mirror reverse writing "MOSS" not only appeared in Liu Cixin’s Supernova Age and China 2185, but also produced intertextuality with the supercomputer of the world’s classic sci-fi movies in some details, such as "Roaming in Space in 2001" and "Alpha City". When the red eye or camera of the supercomputer flashes, there will be a faint prompt sound.

The idea of reverse writing in the mirror of 550W may also be influenced by the classic mirror that says "redrum" and "murder" in reverse. The dual nature of artificial intelligence represented by 550W may be the underlying cause of the two crises. This is a technical ethics issue, a philosophical issue, and even a future realistic issue.

The "Moon Crisis" is the core plot of Wandering Earth 2. If Liu Peiqiang’s clue is the "real universe" directly traced forward, then Tu Hengyu can be said to be a "meta-universe" clue. The virtual reality and life and death were originally antagonistic and either-or, just like the crisis in 2044, but in the face of the crisis of all mankind, people from different countries can unite if they need it, because "there is no human civilization.

The nuclear bomb is used to destroy the moon, which is unity and trust in one dimension, but the key can’t be unlocked, which is division and suspicion in a higher dimension. Only with greater human sacrifice, hands-on operation will have the meaning of unity. Similarly, can the virtual and the real be United? The initial heart of Liu Peiqiang in the real world and Tu Hengyu in the virtual world is "ego", and the responsibility and kindness in human nature become the final choice.

This is not individual heroism, it is "human" collectivity and people’s nature.

Just as Tu Heng-yu’s crossing between the virtual and the real is like "Interstellar" passing through a black hole, he has become a higher-dimensional self, which can send back information to remind human beings of the crisis. In the choice between angels and demons, the continuation of nature is his own god. In this sense, should the community of human destiny include the unity of reality and falsehood, and can it transcend life and death in the process of drawing a blueprint like a foolish man moving mountains in 2500 years? The answer seems to be yes.

Wandering Earth 2 further interprets and deepens the theme, the so-called "Chinese scheme", in the openness of absorbing the nutrition of world science fiction movies. In the sci-fi coalition government, which is almost the same as the real United Nations, the emaciated "Miss Zhou" wearing a Chinese tunic suit with a national flag tells the story of the first healed thigh bone.

Yes, this character’s surname is Zhou. He can evoke Chinese’s collective memory. He can also make a decisive decision based on the belief that "our people are fine" in the face of tidal danger and surveillance cameras. This "last-minute rescue" routine seems to be a familiar way for us.

Wandering Earth 2 clearly shows that the industrial production level of China’s films has reached a new height. The special effects shots are real and full of details, and they dare to show them to the audience frankly, with no intention of concealing or hiding others.

The hardcore degree of paragraphs such as "Space Elevator", "Nuclear Explosion on the Moon", "Returning to Shanghai", "Diving to Restart the Internet Root", "Starting from the Space Station Warrior" and "Stupid Robot Dog" are not inferior in the history and forefront of the world science fiction movie history.

In the combination of narrative and special effects, the structure and rhythm of the so-called emotional drama and hardcore drama are not perfect, but they are basically compact and effective. Moreover, there are only two films in this series at present, and there should be a third film in the future, such as "Helium Flash Crisis in the Sun". If this is the case, the "Wandering Earth" series will show that China’s ability to incubate its own series of films from contemporary IP has reached a new and even global level, and it will also "go global" in the combination of creativity and craftsmanship, in the exploration and interpretation of the theme, and in China’s films.

In this sense, the hardcore of Wandering Earth 2 is not only in the field of science fiction movies, but also a new milestone of science fiction movies in China.

　　From December 19th to 20th, the Central Rural Work Conference was held in Beijing. Before the meeting, the The Politburo Standing Committee (PSC) meeting put forward clear requirements for holding this meeting well and doing a good job in "agriculture, countryside and farmers".

　　Starting from the strategic overall situation of the development of the cause of the party and the country, the General Secretary of the Supreme Leader made important instructions on the work concerning agriculture, countryside and farmers, emphasizing that "to promote Chinese modernization, we must persistently consolidate the agricultural foundation and promote the comprehensive revitalization of the countryside".

　　In China, agriculture is an industry in which nearly 200 million people are employed, and the countryside is the home of nearly 500 million farmers. The problem of farmers in agriculture and rural areas is a fundamental issue related to the national economy and people’s livelihood.

　　In the long scroll of Chinese modernization, how should rural modernization be promoted? How to solidly promote rural revitalization and continue to go deep and practical?

　　From the top priority of rural revitalization — — The perspective of industrial revitalization is for you to interpret.

　　Learn to use the experience of "Ten Million Projects"

　　General Secretary of the Supreme Leader clearly pointed out: "Take promoting the comprehensive revitalization of rural areas as a new journey in the new era ‘ Agriculture, countryside and farmers ’ The general grasp of work, learning to use ‘ Ten million projects ’ Experience, adapt to local conditions, classify policies, step by step, and work for a long time, and concentrate on doing a good job in making a group of practical things that the masses can feel. "

　　The "Ten Million Project", that is, the "Thousand Villages Demonstration and Ten Thousand Villages Renovation" project, was a major project that the Supreme Leader personally planned, deployed and promoted during his work in Zhejiang in 2003.

　　The "Ten Million Project" has been implemented for 20 years, and a scientific path has been explored to strengthen the improvement of rural human settlements, comprehensively promote rural revitalization and promote the construction of beautiful China. Learning to use the "Ten Million Projects" does not require the whole country to use Zhejiang’s rural revitalization model as a "drawing", but to find the right incision and adapt to local conditions, transform regional advantages into development victories, and form a good situation in which the industry is prosperous and the people are rich.

　　Make characteristic and advantageous industries stronger and bigger.

　　In fenghuang town, Xingbin District, Laibin City, Guangxi, as far as the eye can see, pieces of sugarcane can be seen.

　　This is the high-quality sugar cane base in Huang An, Laibin National Modern Agricultural Industrial Park, covering an area of 13,000 mu.

　　On the afternoon of December 14th, General Secretary of the Supreme Leader, who was inspecting Guangxi, came here and boarded the second floor of the octagonal building in the field. When he learned that a large sugarcane harvester can harvest 180 to 200 tons of sugarcane a day, which is equivalent to 180 manual work, the general secretary praised it again and again.

　　In a sugar-making enterprise in fenghuang town, the general secretary has a detailed understanding of sugar-making processes and operation processes such as squeezing and refining. "A cane realizes ‘ Eat dry and squeeze out ’ . This is an industry with high added value! "

　　△ In the "Double-high" sugar cane base in Huang An Village, fenghuang town, Xingbin District, Laibin City, Guangxi, the harvester is mechanically harvesting sugar cane.

　　Sugarcane planting in Guangxi has unique geographical and climatic advantages. Sugarcane planting area and sugar yield have been ranked first in the country for 32 consecutive cropping seasons, and 19 consecutive cropping seasons have accounted for about 60% of the country, which is the main position to safeguard China’s sugar security.

　　"When I visit various places, I have to look at the representative products in our national planning and layout. In the guests, sugar cane is the representative. Today, I came here to see the development pattern of sugarcane planting and sugar industry, and my heart was even more bottomed out. " The general secretary said.

　　"The layout of agricultural production is related to development and security. The planting area should be stable, and the varieties and technologies should be improved to make this characteristic and advantageous industry stronger and bigger. The country supports you, and you should also do a good job in this matter and send sweetness to thousands of families. " The general secretary’s words are earnest.

　　Relying on the characteristic resources of agriculture and rural areas is a key link in the development of rural industries, and only by adapting to local conditions can we work efficiently, laboriously and accurately.

　　Do a good job in characteristic agriculture

　　Cangzhou City, Hebei Province is located on the coast of Bohai Sea, with a high degree of soil salinization, and there are large areas of low-and medium-yield fields and saline-alkali wasteland. In recent years, saline-alkali land has gradually turned into a "big granary" by cultivating wheat varieties with strong salt-alkali tolerance and disease resistance and improving production and cultivation techniques.

　　In May this year, General Secretary of the Supreme Leader made a special trip here to inspect the cultivation, promotion and industrialization of drought-alkali wheat in the field.

　　Looking at the vast fields, the general secretary thought profoundly: "There are 1.5 billion mu of saline-alkali land in China, of which 500 million mu is suitable for growing food. If it can be developed and utilized, it will be of great significance for expanding China’s cultivated land area and safeguarding national food security."

　　△ On June 9, drought-alkali wheat was opened in Xianzhuang District, Huanghua City, Bohai New District, Cangzhou.

　　In 2021, General Secretary of the Supreme Leader went to the Yellow River Delta Agricultural High-tech Industrial Demonstration Zone in Dongying, Shandong Province, and specially inspected the cultivation of salt-tolerant crops.

　　"Last time I saw soybeans, I saw wheat this time. Comprehensive utilization of saline-alkali land is a strategic issue and must be placed in an important position. In addition to coastal areas, there are large areas of saline-alkali land in Songnen Plain in Northeast China, Hetao area in Inner Mongolia and Xinjiang area. It is necessary to make further efforts on the basis of existing achievements and do a good job in this big article on characteristic agriculture in saline-alkali land. " General Secretary of the Supreme Leader pointed out.

　　△ Workers work in the production workshop of Litchi Industrial Park in Maoming, Guangdong. The litchi juice production line here can handle 200 tons of fresh litchi fruit every day.

　　One side of the soil and water can support one side, and one side can also prosper.

　　"Anji White Tea" in Anji, Zhejiang Province, with a brand value of 5.206 billion yuan, ranks eighth in the list of 118 tea regional public brand values. The reason why small tea leaves can enrich the people lies in the unique tea-making skills in the local area.

　　The comprehensive output value of apple industry in Yan ‘an, Shaanxi Province exceeds 30 billion yuan, the yellow flowers in Datong, Shanxi Province are exported to many countries and regions, and the litchi in Maoming, Guangdong Province is famous at home and abroad for its high quality … … Scenes of industrial prosperity highlight the strong kinetic energy of modern agricultural development.

　　Up to now, China has built 180 rural industrial clusters with advantages and characteristics, and the output value of the whole industrial chain has exceeded 4.6 trillion yuan, which has driven more than 10 million farmers.

　　Promoting rural revitalization in an all-round way is an important task of building an agricultural power in the new era.

　　According to local conditions, fully tap and make use of the superior resources in various places, be down-to-earth and work hard, we will be able to vigorously and effectively promote the all-round revitalization of rural areas, so as to accelerate the modernization of agriculture and rural areas and better promote the modernization of Chinese style.

　　Producer: Geng Zhimin

　　Producer Xing Lai

　　Editor-in-Chief Ning Lili

　　Writing, Cheng Yu

　　Visual sense Jiang yuhang

Say goodbye to the old Lingji, and welcome the new Swiss dog to report a bumper year. There are still 16 days to celebrate the Spring Festival in 2018, and the lively pre-sale has already opened the curtain of the Spring Festival movie market.

In mid-January, China Film Report WeChat WeChat official account sent a questionnaire for the Spring Festival to more than ten regional managers and managers of friendly cinemas. The questionnaire is divided into four items, and it is estimated that the box office of the Spring Festival in 2018 will be from the first day to the sixth day, the six-day box office on the first day of the New Year’s Day and the Valentine’s Day box office on February 14, as well as the top three movies that individuals want to see most.

On the last day of January, we published the results of the questionnaire. Let’s get to know the Lunar New Year movie market in the eyes of more than a dozen cinema managers.

From the first day to the sixth day, it is predicted that the lowest is 3 billion and the highest is 4.5 billion.

Question1: How much will the box office be during the six-day holiday from the first day (February 16th) to the sixth day (February 21st) of the 2018 Lunar New Year?

Let’s take a look at the box office results from the first three days to the sixth day: 3.13 billion in 2017, 3.05 billion in 2016 and 1.75 billion yuan in 2015.

Among the 13 movie theater managers who responded to our questionnaire, five movie theater managers predicted that the box office results for the first day to the sixth day of the Spring Festival in 2018 were between 3 billion and 3.5 billion yuan, and one of them was 3 billion yuan, which was lower than last year’s 3.13 billion yuan. It seems that there is insufficient confidence in the market.

stage photo

Cha Ning, the general manager of Bona International Cinema East China, who is estimated to be 3.5 billion yuan, believes that the increase will not be particularly large because the box office of the Spring Festival file is heavily tilted to the third, fourth and fifth tier cities, and the cinema volume and reception capacity of these cities are limited.

Hu Yong, the head of Hubei District of Happiness Blue Ocean International Studios, believes that it will exceed last year’s 3.1 billion yuan, and the growth is not obvious. Another reason is that third-party subsidies are not as strong as last year.

Five theater managers estimated that it was between 3.5 billion yuan and 4 billion yuan, and three managers estimated that it was between 4 billion yuan and 4.5 billion yuan.

Qiu Lei, the general manager of Shun Tak Studios Shanghai, conservatively estimated that the figure was more than 3.5 billion yuan, because he was confident in the quality of several films in this year’s Spring Festival, especially "Catch the Demon 2", which had a high reputation and a high box office as the previous film. As the second film, it is the welfare of fans to show two films in the Spring Festival at the same time.

Stills of "Detective Chinatown 2"

Liu Yunhui, the general manager of Guangzhou Zhongying Phoenix Studios, estimated that the number of screens increased by 600 million yuan compared with the same period of last year. Besides the increase in the number of screens and the high quality of the four major films, he also put forward two viewpoints: the audience’s viewing atmosphere and habits are better than that of the same period of last year, especially when the films bring more new viewing faces, and the Spring Festival family reunion will gradually form the entertainment way for the whole family to watch movies, bringing more topics before and after tea; The 2018 Spring Festival movies cover audiences of all ages, and "Catch the Demon 2" is a family fun, with strong IP and can drive the story of the girl country in the eyes of different ages, which is quite Wolf Warriors 2 temperament, showing the country’s prosperity and bringing its own aura.

Operation Red Sea stills

Lin Jinbin, the general manager of Dongguan East Wing International Studios, who gave a figure of 4 billion, predicted that there would be about 3 billion yuan in the next five days after the "one billion plus" on the first day.

Cao Gang, director of market operation of Shanghai United Cinema Line, who gave a forecast of more than 4.5 billion yuan, speculated that "there were 45,000 screens in the same period last year and more than 52,000 screens this year, and the box office is expected to increase by more than 30% year-on-year."

Go. "

13 cinema managers’ prediction of six-day box office from grade one to grade six

Will the "one billion plus" on New Year’s Day hit a new high at the box office in a single day?

Question2: How much will the box office be on the first day of the Spring Festival in 2018 (February 16th)?

In 2017, 2016 and 2015, the box office exceeded 800 million yuan, 650 million yuan and 330 million yuan respectively.

For the box office forecast of the New Year’s Day in 2018, three theater managers predicted that it would be below 1 billion yuan, five managers predicted that it would be around 1 billion yuan, and five managers predicted that it would be above 1 billion yuan.

Wang Zheng, the marketing manager of Jinyi Studios Beijing Chaoyang Joy City Store, which is estimated to be 700 million yuan, believes that the forecast is 100 million less than that of the same day last year because there are no films and 2D films on New Year’s Eve.

Pang Zheng, manager of Lumiere Studios’ Tantian Street Store, which is also on Chaoyang North Road in Beijing, is more optimistic about the first film market. "As far as the current pre-sale analysis is concerned, the number of times released by" Catch the Demon 2 "is full under the influence of ticket compensation. The overall box office should exceed 1 billion yuan. "

Cha Ning, general manager of Bona International Cinema in East China, also thinks that the first day will exceed 1 billion yuan. She added that the price limit of several blockbusters has increased this year.

Cao Gang, director of market operation of Shanghai United Cinema Line, said, "The pre-sale has exceeded 50 million three weeks in advance, and the daily box office is estimated to increase by 20% year-on-year."

13 cinema managers’ prediction of single-day box office on New Year’s Day

Can Valentine’s Day the day before New Year’s Eve reach 400 million box office?

Question3: What will be the box office for Valentine’s Day in 2018?

For the box office of Valentine’s Day in 2018, three theater managers predicted that the box office would be within 100 million yuan, three managers predicted that the box office would be between 200 million yuan and 300 million yuan, and seven managers predicted that the box office would be between 400 million yuan and 500 million yuan.

Liu Yunhui, general manager of Guangzhou Zhongying Phoenix Studios, who predicted the box office of 80 million yuan, believes that this year’s Valentine’s Day is the day before New Year’s Eve, and the audience is basically busy with the Spring Festival. At present, there is only one movie "Journey to the West" to watch.

Hu Yong, head of Happiness Blue Ocean International Studios in Hubei, also said that the box office output at this time is mainly in third-and fourth-tier cities, but people are preparing for the New Year, and their attention may decrease on Valentine’s Day.

Qiu Lei, general manager of Dexin Studios Shanghai, analyzed, "Last year’s Valentine’s Day box office was 390 million yuan, and this year it is estimated to be 500 million yuan. Because many enterprises will have an early holiday near the Chinese New Year, Journey to the West will definitely make a major contribution to the box office, because many studios and audiences want to see the quality of Journey to the West, and there are many blockbusters in the Spring Festival. It is also an adventure for Journey to the West to the Girl’s Country to do so. Many studios will increase Journey to the Girl’s Country with good screening effect.

13 cinema managers’ prediction of Valentine’s Day box office

The cinema manager personally wants to see: Catch the Demon 2, Chinatown Detective 2, Operation Red Sea.

Question4: What are the first three movies that people want to see in the following Spring Festival movies (1 Journey to the Daughter’s Country, 2 Detective Cases in Chinatown, 3 Catch the Demon, 4, 5, 6, 7 Operation Red Sea, 8, 9,10 and 11)?

According to the survey, the top three films are: Catch the Demon 2, Detective Chinatown 2, Operation Red Sea.

List of the top three movies that cinema managers want to see most.

Statistics of 12 managers’ voting

The theater regional managers and theater managers who helped China Film Report to complete the questionnaire on WeChat WeChat official account mainly came from Beijing, Shanghai and Guangdong, including a theater marketing manager and a theater manager representative in a fourth-tier city, which are collectively referred to as theater managers for the convenience of writing. Here, I would also like to thank many cinema managers for their participation and cooperation, and wish the major cinemas a new high in revenue during the Spring Festival.

Special feature of 1905 film network On March 12th, the light comedy of love was released in China. The film focuses on the difficulties encountered by China students when they drifted to Britain. In order to make up for the unexpected mistake that Gu Dabai was about to be deported because he failed to renew his contract in time, Jin Tian, a good brother, came up with a "good idea" to hide the truth and keep Gu Dabai.

The story took place in England, and the audience also followed the movie on a cloud tour. In addition to St. Paul’s Cathedral, Thames, London Eye and other famous attractions, the scenery of unknown blocks is also a major attraction of the film. These blocks have a British texture, showing the real "London style".

In this issue, I specially invited the director of Legal Companion to share with us his film shooting strategy in Britain."The preparatory period for the film" Legal Companion "to shoot in the UK has been almost one year, because we have to look at the scenery first, and then we have to declare this permission to the British government quickly. Only when we get the permission can we really shoot."

"Basically, if you want to finish this film, you have to follow the previous production plan and finish what you planned to finish at every fixed time, because Britain is a country that pays great attention to commitments and contracts. All the forms we fill in and the applications we submit are official commitments, so we have given people this commitment, and we must complete this work within this commitment. "

At the beginning of the film, Gu Dabai rode through the block. In fact, this seemingly ordinary living shooting location also needs to be fully prepared.

"With the understanding of the domestic audience, the traditional filing in our country is different. Britain is a country with private ownership, and its land is allowed to be privately held. Therefore, when I shoot in one street, it is very likely that I will shoot three streets together. The former street belongs to the government and the third street belongs to an individual. After I submit the report to the government, I have to get his permission from the owner of the individual before I can get the whole scene. "

In addition to the beautiful scenery in the film, the casting and dressing of the film are also very British. The leading actor with a mixed-race face studied in Britain during his undergraduate period and lived in the same semi-basement house as in the film. "Semi-underground is a place to live that particularly reflects the identity of international students." We can also get a glimpse of the real life of "Ying Piao" in the movie by renting the basement in the wet England.

In recent years, it is not uncommon for China films to be filmed in foreign countries. The film released in this year’s Spring Festival not long ago also encountered many production problems when shooting in Japan. When shooting in a busy street, the crew must go through the consent of every store and every business before shooting in this street, and they must apologize to the residents and passers-by who are disturbed by it.

Cultural differences in different countries and different modes of film industry production have brought various difficulties to China films with transnational cooperation. To overcome these difficulties, what we have to do is to know the local culture in advance and do our homework well. Respecting and being honest with each other is the essence of making a good transnational cooperative film. Director Huang Lei bluntly said: "You must give the other party enough respect before the other party will give you respect and allow you to shoot."

Transnational cooperation in China movies can not only bring viewers the viewing experience of cloud tourism in different regions, but also bring different cultural environment cores to the story of the movie itself. In order to avoid the story and the beautiful scenery, we must have a deep understanding of the location of the story, and whether the location can fit the regional and cultural background of the story is also the direction that filmmakers need to pay attention to in transnational cooperative films.

"The style of the whole British society is not only focused on the beautiful scenery, but also has more British people, British life, British social things, and some bits and pieces of details, so these details constitute the whole overseas culture. It is particularly realistic to let our characters live in such an environment."

Legal Companion can successfully bring the audience the real life state of young people overseas, which is inseparable from the early understanding of British regional culture. The cross-border cooperative shooting strategy shared by director Huang Lei also gives filmmakers, especially young directors who want to shoot similar themes, some experiences that can be used for reference. "I think it is still necessary to understand the people in this place, their daily thinking habits and living habits, and then what will happen when different cultures collide."

Nowadays, China movies with transnational cooperation emerge one after another. While putting an exotic coat on the environment, we hope that the movies can tell the stories of people in different cultural backgrounds at the same time. Now we have a series of successful examples, such as "Legal Companion", and we are looking forward to more and more such films.

The director’s observation of today’s film review;Many people may think that shooting abroad is a special pleasure, but it is endless pressure for directors. Shooting abroad means higher costs, and the accommodation and travel of the whole crew will become a big account. Shooting abroad may also face more unknowns and risks, and the director needs to make a quick decision in a limited time and finish shooting efficiently. Because I watched the director’s special film in Japan, I feel confident like him, and sometimes I hesitate and make trouble, which is even more challenging for the new director. (Wu Zhiying)

On January 16th, 2024 BYD Dream Day was held tonight. The conference described the intelligent picture of BYD, and BYD also announced a brand-new DiPilot intelligent driving system.

According to the official introduction, the DiPilot intelligent driving system will be renamed for each version:

In addition, NOA high-speed navigation-assisted driving is named "high-speed navigation" and NOA city navigation-assisted driving is named "city navigation".

BYD also announced the OTA upgrade schedule this year. The IT House is summarized as follows:

Q1, 2024: Mobile phone remote parking, intelligent driving interactive interface optimization, city navigation, high-speed navigation, etc.

Q2 in 2024: Low-speed emergency braking, narrow passage, short-distance parking service, etc.